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1u9x

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[[Image:1u9x.gif|left|200px]]
[[Image:1u9x.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1u9x |SIZE=350|CAPTION= <scene name='initialview01'>1u9x</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1u9x", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=IHJ:9-CYCLOPENTYL-6-{2-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPOXY]-PHENYLAMINO}-9H-PURINE-2-CARBONITRILE'>IHJ</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1u9x| PDB=1u9x | SCENE= }}
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|RELATEDENTRY=[[1u9v|1U9V]], [[1u9w|1U9W]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9x OCA], [http://www.ebi.ac.uk/pdbsum/1u9x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u9x RCSB]</span>
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}}
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'''Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABJ688'''
'''Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABJ688'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Cowan-Jacob, S W.]]
[[Category: Cowan-Jacob, S W.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: sulfhydryl proteinase]]
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[[Category: Sulfhydryl proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:57:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:07:22 2008''
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Revision as of 07:57, 3 May 2008

Image:1u9x.gif

Template:STRUCTURE 1u9x

Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABJ688


Overview

Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhibitors.

About this Structure

1U9X is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K., Altmann E, Cowan-Jacob SW, Missbach M, J Med Chem. 2004 Nov 18;47(24):5833-6. PMID:15537340 Page seeded by OCA on Sat May 3 10:57:02 2008

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