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Cyclophilin
From Proteopedia
(Difference between revisions)
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | * Cyclophilin-A | + | * Cyclophilin-A or peptidyl-prolyl cis-trans isomerase A |
| - | **[[2x25]], [[2x2a]], [[3k0m]], [[3k0n]], [[1w8l]], [[1w8m]], [[1w8v]], [[1rmh]], [[2cpl]] – hCyp-A – human<br /> | + | **[[2x25]], [[2x2a]], [[3k0m]], [[3k0n]], [[1w8l]], [[1w8m]], [[1w8v]], [[1rmh]], [[2cpl]], [[5kv7]], [[5kv6]], [[5kv5]], [[5kv4]], [[5kv3]], [[5kv2]], [[5kv1]], [[5kv0]], [[5kuz]], [[5kuw]], [[5kuv]], [[5kuu]], [[5kus]], [[5kur]], [[5kuq]], [[5kuo]], [[5kun]], [[4kul]], [[5f66]], [[4yup]], [[4yuo]], [[4yun]], [[4yum]], [[4yul]], [[4yuk]], [[4yuj]], [[4yui]], [[4yuh]], [[4yug]], [[2n0t]] – hCyp-A – human<br /> |
| - | **[[1oca]] – hCyp-A - NMR<br /> | + | **[[1oca]], [[2mzu]] – hCyp-A - NMR<br /> |
**[[3k0o]], [[3k0p]], [[3k0q]], [[3k0r]], [[2alf]] – hCyp-A (mutant)<br /> | **[[3k0o]], [[3k0p]], [[3k0q]], [[3k0r]], [[2alf]] – hCyp-A (mutant)<br /> | ||
**[[4dgd]] - RmCyp-A (mutant) – Rhesus macaque <br /> | **[[4dgd]] - RmCyp-A (mutant) – Rhesus macaque <br /> | ||
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**[[4e1q]] – Cyp-A – wheat<br /> | **[[4e1q]] – Cyp-A – wheat<br /> | ||
**[[4eyv]] – Cyp-A – ''Piriformospora indica''<br /> | **[[4eyv]] – Cyp-A – ''Piriformospora indica''<br /> | ||
| + | **[[5ex2]], [[5ex1]] – Cyp-A – ''Hirschia baltica''<br /> | ||
* Cyclophilin-A complex | * Cyclophilin-A complex | ||
| Line 38: | Line 39: | ||
**[[3odi]], [[3odl]] – hCyp-A+voclosporin<br /> | **[[3odi]], [[3odl]] – hCyp-A+voclosporin<br /> | ||
**[[2x2d]], [[1m9c]], [[1m9d]], [[1m9e]], [[1m9f]], [[1m9x]], [[1m9y]], [[1awq]], [[1awr]], [[1aws]], [[1awt]], [[1awu]], [[1awv]], [[1ak4]], [[1fgl]] - hCyp-A+HIV-1 N-terminal capsid domain<br /> | **[[2x2d]], [[1m9c]], [[1m9d]], [[1m9e]], [[1m9f]], [[1m9x]], [[1m9y]], [[1awq]], [[1awr]], [[1aws]], [[1awt]], [[1awu]], [[1awv]], [[1ak4]], [[1fgl]] - hCyp-A+HIV-1 N-terminal capsid domain<br /> | ||
| + | **[[5fjb]] - hCyp-A + HIV-1 gag protein <br /> | ||
**[[4dga]], [[4dgb]], [[4dgc]] - RmCyp-A+HIV-1 Cyp-binding domain capsid protein (mutant) <br /> | **[[4dga]], [[4dgb]], [[4dgc]] - RmCyp-A+HIV-1 Cyp-binding domain capsid protein (mutant) <br /> | ||
**[[4dge]] - RmCyp-A (mutant) +HIV-1 Cyp-binding domain capsid protein (mutant) <br /> | **[[4dge]] - RmCyp-A (mutant) +HIV-1 Cyp-binding domain capsid protein (mutant) <br /> | ||
**[[1zkf]] – hCyp-A+suc-AGPF-pNA<br /> | **[[1zkf]] – hCyp-A+suc-AGPF-pNA<br /> | ||
| - | **[[1ynd]], [[1nmk]] – hCyp-A+ sanglifehrin<br /> | + | **[[1ynd]], [[1nmk]], [[5ta4]], [[5ta2]], [[5t9z]], [[5t9w]], [[5t9u]] – hCyp-A+ sanglifehrin derivaive<br /> |
| + | **[[4n1s]], [[4n1r]], [[4n1q]], [[4n1p]], [[4n1o]], [[4n1n]], [[4n1m]] – hCyp-A + inhibitor<br /> | ||
**[[2cyh]], [[3cyh]], [[4cyh]], [[5cyh]] - hCyp-A+dipeptide<br /> | **[[2cyh]], [[3cyh]], [[4cyh]], [[5cyh]] - hCyp-A+dipeptide<br /> | ||
| - | **[[1vbs]], [[1vbt]] – hCyp-A+tetrapeptide<br /> | + | **[[1vbs]], [[1vbt]], [[2ms4]] – hCyp-A+tetrapeptide<br /> |
| + | **[[4ipz]] - hCyp-A (mutant) + peptide <br /> | ||
**[[1vdn]] – yCyp-A+peptidyl coumarin – yeast<br /> | **[[1vdn]] – yCyp-A+peptidyl coumarin – yeast<br /> | ||
**[[1lop]] - EcCyp-A+peptidyl nitroanilide - ''Escherichia coli''<br /> | **[[1lop]] - EcCyp-A+peptidyl nitroanilide - ''Escherichia coli''<br /> | ||
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**[[1jns]], [[1jnt]] – EcCyp-C - NMR<BR /> | **[[1jns]], [[1jnt]] – EcCyp-C - NMR<BR /> | ||
| - | * Cyclophilin-D | + | * Cyclophilin-D or peptidyl-prolyl cis-trans isomerase F |
**[[2bit]], [[3qyu]] – hCyp-D<br /> | **[[2bit]], [[3qyu]] – hCyp-D<br /> | ||
| + | **[[4zsd]], [[4o8i]], [[4o8h]] - hCyp-D (mutant) <br /> | ||
**[[2biu]] – hCyp-D+DMSO<br /> | **[[2biu]] – hCyp-D+DMSO<br /> | ||
**[[2z6w]] - hCyp-D+cyclosporin A<br /> | **[[2z6w]] - hCyp-D+cyclosporin A<br /> | ||
| - | **[[3r49]], [[3r4g]], [[3r54]], [[3r56]], [[3r57]], [[3r59]], [[3rcf]], [[3rcg]], [[3rci]], [[3rck]], [[3rcl]], [[3rd9]], [[3rda]], [[3rdb]], [[3rdc]], [[4j58]], [[4j59]], [[4j5a]], [[4j5b]], [[4j5c]], [[4j5d]] – hCyp-D (mutant) + inhibitor<br /> | + | **[[5a0e]] - hCyp-D (mutant) + cyclosporin A<br /> |
| + | **[[4tot]] – hCyp-D + polypeptide inhibitor<br /> | ||
| + | **[[3r49]], [[3r4g]], [[3r54]], [[3r56]], [[3r57]], [[3r59]], [[3rcf]], [[3rcg]], [[3rci]], [[3rck]], [[3rcl]], [[3rd9]], [[3rda]], [[3rdb]], [[3rdc]], [[4j58]], [[4j59]], [[4j5a]], [[4j5b]], [[4j5c]], [[4j5d]], [[5ccs]], [[5ccr]], [[5ccq]], [[5ccn]], [[5cbw]], [[5cbv]], [[5cbu]], [[5cbt]], [[4zsc]], [[4xnc]], [[4j5e]] – hCyp-D (mutant) + inhibitor<br /> | ||
| - | * Cyclophilin-E | + | * Cyclophilin-E or peptidyl-prolyl cis-trans isomerase E |
**[[2kyx]], [[1zmf]] – hCyp-E PPIASE domain<br /> | **[[2kyx]], [[1zmf]] – hCyp-E PPIASE domain<br /> | ||
| - | **[[2r99]] - hCyp-E ABH-like domain<br /> | + | **[[2r99]], [[3uch]] - hCyp-E ABH-like domain<br /> |
**[[2cqb]] – hCyp-E RNA recognition motif<br /> | **[[2cqb]] – hCyp-E RNA recognition motif<br /> | ||
**[[2ck1]], [[2cmt]] – Cyp-E – ''Schistosoma mansoni''<br /> | **[[2ck1]], [[2cmt]] – Cyp-E – ''Schistosoma mansoni''<br /> | ||
Revision as of 10:25, 6 April 2017
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3D Structures of Cyclophilin
Updated on 06-April-2017
References
- ↑ Stamnes MA, Rutherford SL, Zuker CS. Cyclophilins: a new family of proteins involved in intracellular folding. Trends Cell Biol. 1992 Sep;2(9):272-6. PMID:14731520
- ↑ Zhou D, Mei Q, Li J, He H. Cyclophilin A and viral infections. Biochem Biophys Res Commun. 2012 Aug 10;424(4):647-50. doi:, 10.1016/j.bbrc.2012.07.024. Epub 2012 Jul 16. PMID:22814107 doi:http://dx.doi.org/10.1016/j.bbrc.2012.07.024
- ↑ Hatziioannou T, Perez-Caballero D, Cowan S, Bieniasz PD. Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells. J Virol. 2005 Jan;79(1):176-83. PMID:15596813 doi:http://dx.doi.org/10.1128/JVI.79.1.176-183.2005
- ↑ Lammers M, Neumann H, Chin JW, James LC. Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. Nat Chem Biol. 2010 May;6(5):331-7. Epub 2010 Apr 4. PMID:20364129 doi:10.1038/nchembio.342
