Cyclophilin

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* Cyclophilin-A or peptidyl-prolyl cis-trans isomerase A
* Cyclophilin-A or peptidyl-prolyl cis-trans isomerase A
-
**[[2x25]], [[2x2a]], [[3k0m]], [[3k0n]], [[1w8l]], [[1w8m]], [[1w8v]], [[1rmh]], [[2cpl]], [[5kv7]], [[5kv6]], [[5kv5]], [[5kv4]], [[5kv3]], [[5kv2]], [[5kv1]], [[5kv0]], [[5kuz]], [[5kuw]], [[5kuv]], [[5kuu]], [[5kus]], [[5kur]], [[5kuq]], [[5kuo]], [[5kun]], [[4kul]], [[5f66]], [[4yup]], [[4yuo]], [[4yun]], [[4yum]], [[4yul]], [[4yuk]], [[4yuj]], [[4yui]], [[4yuh]], [[4yug]], [[2n0t]] – hCyp-A – human<br />
+
**[[2x25]], [[2x2a]], [[3k0m]], [[3k0n]], [[1w8l]], [[1w8m]], [[1w8v]], [[1rmh]], [[2cpl]], [[5kv7]], [[5kv6]], [[5kv5]], [[5kv4]], [[5kv3]], [[5kv2]], [[5kv1]], [[5kv0]], [[5kuz]], [[5kuw]], [[5kuv]], [[5kuu]], [[5kus]], [[5kur]], [[5kuq]], [[5kuo]], [[5kun]], [[4kul]], [[5f66]], [[4yup]], [[4yuo]], [[4yun]], [[4yum]], [[4yul]], [[4yuk]], [[4yuj]], [[4yui]], [[4yuh]], [[4yug]], [[2n0t]], [[5kul]] – hCyp-A – human<br />
**[[1oca]], [[2mzu]] – hCyp-A - NMR<br />
**[[1oca]], [[2mzu]] – hCyp-A - NMR<br />
**[[3k0o]], [[3k0p]], [[3k0q]], [[3k0r]], [[2alf]] – hCyp-A (mutant)<br />
**[[3k0o]], [[3k0p]], [[3k0q]], [[3k0r]], [[2alf]] – hCyp-A (mutant)<br />
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**[[2a2c]], [[1cwa]], [[1cwb]], [[1cwc]], [[2x2c]] – hCyp-A+cyclosporin A<br />
**[[2a2c]], [[1cwa]], [[1cwb]], [[1cwc]], [[2x2c]] – hCyp-A+cyclosporin A<br />
**[[3cys]] - hCyp-A+cyclosporin A - NMR<br />
**[[3cys]] - hCyp-A+cyclosporin A - NMR<br />
-
**[[1cwj]], [[1bck]], [[1cwi]], [[1cwo]], [[1cwf]], [[1cwh]], [[1cwk]], [[1cwl]], [[1cwm]], [[1mik]] - hCyp-A+cyclosporin A derivative<br />
+
**[[1cwj]], [[1bck]], [[1cwi]], [[1cwo]], [[1cwf]], [[1cwh]], [[1cwk]], [[1cwl]], [[1cwm]], [[1mik]], [[5hsv]] - hCyp-A+cyclosporin A derivative<br />
**[[2rma]], [[2rmb]] - hCyp-A+cyclosporin A+cyclosporin A derivative<br />
**[[2rma]], [[2rmb]] - hCyp-A+cyclosporin A+cyclosporin A derivative<br />
**[[1mf8]], [[1m63]] - hCyp-A+cyclosporin A+ calcineurin subunits A,B<br />
**[[1mf8]], [[1m63]] - hCyp-A+cyclosporin A+ calcineurin subunits A,B<br />
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**[[1zkf]] – hCyp-A+suc-AGPF-pNA<br />
**[[1zkf]] – hCyp-A+suc-AGPF-pNA<br />
**[[1ynd]], [[1nmk]], [[5ta4]], [[5ta2]], [[5t9z]], [[5t9w]], [[5t9u]] – hCyp-A+ sanglifehrin derivaive<br />
**[[1ynd]], [[1nmk]], [[5ta4]], [[5ta2]], [[5t9z]], [[5t9w]], [[5t9u]] – hCyp-A+ sanglifehrin derivaive<br />
-
**[[4n1s]], [[4n1r]], [[4n1q]], [[4n1p]], [[4n1o]], [[4n1n]], [[4n1m]] – hCyp-A + inhibitor<br />
+
**[[4n1s]], [[4n1r]], [[4n1q]], [[4n1p]], [[4n1o]], [[4n1n]], [[4n1m]], [[3rrd]], [[5noz]], [[5noy]], [[5nox]], [[5nou]], [[5nov]], [[5now]], [[5nor]], [[5nos]], [[5not]], [[5noq]], [[5lud]] – hCyp-A + inhibitor<br />
**[[2cyh]], [[3cyh]], [[4cyh]], [[5cyh]] - hCyp-A+dipeptide<br />
**[[2cyh]], [[3cyh]], [[4cyh]], [[5cyh]] - hCyp-A+dipeptide<br />
**[[1vbs]], [[1vbt]], [[2ms4]] – hCyp-A+tetrapeptide<br />
**[[1vbs]], [[1vbt]], [[2ms4]] – hCyp-A+tetrapeptide<br />

Revision as of 10:36, 16 April 2018

Human Cyclophilin-A (rust, olive, turquois, dark green, khaki) complex with cyclosporin A (green, cyan, aqua, neon green, blue) (PDB entry 2x2c)

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3D Structures of Cyclophilin

Updated on 16-April-2018

References

  1. Stamnes MA, Rutherford SL, Zuker CS. Cyclophilins: a new family of proteins involved in intracellular folding. Trends Cell Biol. 1992 Sep;2(9):272-6. PMID:14731520
  2. Zhou D, Mei Q, Li J, He H. Cyclophilin A and viral infections. Biochem Biophys Res Commun. 2012 Aug 10;424(4):647-50. doi:, 10.1016/j.bbrc.2012.07.024. Epub 2012 Jul 16. PMID:22814107 doi:http://dx.doi.org/10.1016/j.bbrc.2012.07.024
  3. Hatziioannou T, Perez-Caballero D, Cowan S, Bieniasz PD. Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells. J Virol. 2005 Jan;79(1):176-83. PMID:15596813 doi:http://dx.doi.org/10.1128/JVI.79.1.176-183.2005
  4. Lammers M, Neumann H, Chin JW, James LC. Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. Nat Chem Biol. 2010 May;6(5):331-7. Epub 2010 Apr 4. PMID:20364129 doi:10.1038/nchembio.342

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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