1uaa

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[[Image:1uaa.jpg|left|200px]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uaa OCA], [http://www.ebi.ac.uk/pdbsum/1uaa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uaa RCSB]</span>
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'''E. COLI REP HELICASE/DNA COMPLEX'''
'''E. COLI REP HELICASE/DNA COMPLEX'''
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[[Category: Korolev, S.]]
[[Category: Korolev, S.]]
[[Category: Waksman, G.]]
[[Category: Waksman, G.]]
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[[Category: complex (helicase/dna)]]
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[[Category: Dna unwinding]]
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[[Category: dna unwinding]]
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[[Category: Helicase]]
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[[Category: helicase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:07:29 2008''
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Revision as of 07:57, 3 May 2008

Image:1uaa.jpg


PDB ID 1uaa

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1uaa, resolution 3.00Å ()
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



E. COLI REP HELICASE/DNA COMPLEX


Overview

Crystal structures of binary and ternary complexes of the E. coli Rep helicase bound to single-stranded (ss) DNA or ssDNA and ADP were determined to a resolution of 3.0 A and 3.2 A, respectively. The asymmetric unit in the crystals contains two Rep monomers differing from each other by a large reorientation of one of the domains, corresponding to a swiveling of 130 degrees about a hinge region. Such domain movements are sufficiently large to suggest that these may be coupled to translocation of the Rep dimer along DNA. The ssDNA binding site involves the helicase motifs Ia, III, and V, whereas the ADP binding site involves helicase motifs I and IV. Residues in motifs II and VI may function to transduce the allosteric effects of nucleotides on DNA binding. These structures represent the first view of a DNA helicase bound to DNA.

About this Structure

1UAA is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP., Korolev S, Hsieh J, Gauss GH, Lohman TM, Waksman G, Cell. 1997 Aug 22;90(4):635-47. PMID:9288744 Page seeded by OCA on Sat May 3 10:57:47 2008

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