1uas

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[[Image:1uas.jpg|left|200px]]
[[Image:1uas.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1uas |SIZE=350|CAPTION= <scene name='initialview01'>1uas</scene>, resolution 1.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1uas", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-galactosidase Alpha-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.22 3.2.1.22] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1uas| PDB=1uas | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uas OCA], [http://www.ebi.ac.uk/pdbsum/1uas PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uas RCSB]</span>
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}}
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'''Crystal structure of rice alpha-galactosidase'''
'''Crystal structure of rice alpha-galactosidase'''
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[[Category: Mizuno, H.]]
[[Category: Mizuno, H.]]
[[Category: Momma, M.]]
[[Category: Momma, M.]]
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[[Category: beta-alpha-barrel]]
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[[Category: Beta-alpha-barrel]]
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[[Category: greek key motif]]
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[[Category: Greek key motif]]
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[[Category: tim-barrel]]
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[[Category: Tim-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:58:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:07:41 2008''
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Revision as of 07:58, 3 May 2008

Image:1uas.jpg

Template:STRUCTURE 1uas

Crystal structure of rice alpha-galactosidase


Overview

alpha-Galactosidases catalyze the hydrolysis of alpha-1,6-linked galactosyl residues from galacto-oligosaccharides and polymeric galacto-(gluco)mannans. The crystal structure of rice alpha-galactosidase has been determined at 1.5A resolution using the multiple isomorphous replacement method. The structure consisted of a catalytic domain and a C-terminal domain and was essentially the same as that of alpha-N-acetylgalactosaminidase, which is the same member of glycosyl hydrolase family 27. The catalytic domain had a (beta/alpha)8-barrel structure, and the C-terminal domain was made up of eight beta-strands containing a Greek key motif. The structure was solved as a complex with d-galactose, providing a mode of substrate binding in detail. The d-galactose molecule was found bound in the active site pocket on the C-terminal side of the central beta-barrel of the catalytic domain. The d-galactose molecule consisted of a mixture of two anomers present in a ratio equal to their natural abundance. Structural comparisons of rice alpha-galactosidase with chicken alpha-N-acetylgalactosaminidase provided further understanding of the substrate recognition mechanism in these enzymes.

About this Structure

1UAS is a Single protein structure of sequence from Oryza sativa. Full crystallographic information is available from OCA.

Reference

Crystal structure of rice alpha-galactosidase complexed with D-galactose., Fujimoto Z, Kaneko S, Momma M, Kobayashi H, Mizuno H, J Biol Chem. 2003 May 30;278(22):20313-8. Epub 2003 Mar 25. PMID:12657636 Page seeded by OCA on Sat May 3 10:58:44 2008

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