This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5glg
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==The novel function of Osm1 under anaerobic condition in the ER was revealed by crystal structure of Osm1, a soluble fumarate reductase in yeast== | |
| - | + | <StructureSection load='5glg' size='340' side='right' caption='[[5glg]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5glg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GLG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.6 1.3.1.6] </span></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5glg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5glg OCA], [http://pdbe.org/5glg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5glg RCSB], [http://www.ebi.ac.uk/pdbsum/5glg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5glg ProSAT]</span></td></tr> |
| - | [[Category: Choi, J | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/OSM1_YEAST OSM1_YEAST]] Irreversibly catalyzes the reduction of fumarate to succinate. Together with the second isozyme of soluble fumarate reductase (FRD1), essential for anaerobic growth. Involved in maintaining redox balance during oxygen deficiency conditions. Reduction of fumarate is the main source of succinate during fermentation, and under anaerobic conditions, the formation of succinate is strictly required for the reoxidation of FADH(2).<ref>PMID:12949191</ref> <ref>PMID:17345583</ref> <ref>PMID:9587404</ref> <ref>PMID:9711846</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Choi, J Y]] | ||
| + | [[Category: Park, H H]] | ||
| + | [[Category: Fad]] | ||
| + | [[Category: Fumarate reductase]] | ||
| + | [[Category: Osm1]] | ||
Revision as of 10:19, 10 September 2017
The novel function of Osm1 under anaerobic condition in the ER was revealed by crystal structure of Osm1, a soluble fumarate reductase in yeast
| |||||||||||
Categories: Oxidoreductase | Choi, J Y | Park, H H | Fad | Fumarate reductase | Osm1
