5nkn
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of an Anticalin-colchicine complex== | |
| - | + | <StructureSection load='5nkn' size='340' side='right' caption='[[5nkn]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5nkn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NKN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LOC:N-[(7S)-1,2,3,10-TETRAMETHOXY-9-OXO-6,7-DIHYDRO-5H-BENZO[D]HEPTALEN-7-YL]ETHANAMIDE'>LOC</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nkn OCA], [http://pdbe.org/5nkn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nkn RCSB], [http://www.ebi.ac.uk/pdbsum/5nkn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nkn ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NGAL_HUMAN NGAL_HUMAN]] Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.<ref>PMID:12453413</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Barkovskiy, M]] | ||
[[Category: Eichinger, A]] | [[Category: Eichinger, A]] | ||
| - | [[Category: Barkovskiy, M]] | ||
[[Category: Skerra, A]] | [[Category: Skerra, A]] | ||
| + | [[Category: Beta-barrel]] | ||
| + | [[Category: Colchicine]] | ||
| + | [[Category: Lcn2]] | ||
| + | [[Category: Lipocalin]] | ||
| + | [[Category: Ngal]] | ||
| + | [[Category: Protein engineering]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 05:51, 4 April 2018
Crystal structure of an Anticalin-colchicine complex
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