5nl1
From Proteopedia
(Difference between revisions)
m (Protected "5nl1" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Shigella IpaA-VBS3/TBS in complex with the Talin VBS1 domain 488-512== | |
| - | + | <StructureSection load='5nl1' size='340' side='right' caption='[[5nl1]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5nl1]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NL1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nl1 OCA], [http://pdbe.org/5nl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nl1 RCSB], [http://www.ebi.ac.uk/pdbsum/5nl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nl1 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. [[http://www.uniprot.org/uniprot/IPAA_SHIFL IPAA_SHIFL]] Rapidly associates with the first 265 amino acids of vinculin after bacteria-cell contact. This interaction is critical for efficient Shigella uptake. IpaA acts as a potent activator of vinculin and increase its ability to interact with F-actin. The complex IpaA-vinculin induces F-actin depolymerization along with the occasional formation of actin filament bundles.<ref>PMID:9184218</ref> <ref>PMID:10545097</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bou-Nader, C]] | ||
| + | [[Category: Fontecave, M]] | ||
| + | [[Category: Nhieu, G Tran Van]] | ||
| + | [[Category: Pecqueur, L]] | ||
| + | [[Category: Valencia-Gallardo, C]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 05:20, 16 May 2018
Shigella IpaA-VBS3/TBS in complex with the Talin VBS1 domain 488-512
| |||||||||||
