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Dehalogenase

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Haloalkane dehalogenase (HDH)
+
*Haloalkane dehalogenase
-
**[[2had]], [[1ede]], [[2pky]], [[2yxp]] – XaHDH – ''Xanthobacter autotrophicus''<br />
+
**[[4c6h]] – RbHLD + hexanol – ''Rhodobacteraceae'' <br />
-
**[[1hde]], [[1be0]], [[1bee]], [[1bez]] – XaHDH (mutant)<br />
+
**[[1bn6]], [[1bn7]], [[4kaf]], [[4kaa]], [[4kac]] – RrHLD – ''Rhodococcus rhodochrous''<br />
-
**[[1bn6]], [[1bn7]], [[4kaa]], [[4kac]], [[4kaf]] – RrHDH – ''Rhodococcus rhodochrous'' <br />
+
**[[5y2x]] – RrHLD (mutant) <br />
-
**[[2v9z]], [[4wcv]] – RrHDH (mutant) <br />
+
**[[4e46]] – RrHLD + propanol <br />
-
**[[1cv2]] – SpHDH – ''Sphingomonas paucimobilis''<br />
+
**[[3u1t]] – HLD DmmA – marine <br />
-
**[[4h77]] – SphHDH – ''Sphignobium''<br />
+
**[[2had]], [[1ede]], [[2pky]], [[2yxp]], [[1edb]] – XaHLD – ''Xanthobacter autotrophicus'' <br />
-
**[[4h7d]], [[4h7k]] – SphHDH (mutant)<br />
+
**[[1be0]], [[1bee]], [[1hde]], [[1bez]] – XaHLD (mutant) <br />
-
**[[2xt0]] – HDH – ''Plesiocystis pacifica''<br />
+
**[[3wi7]] – AtHLD DatA – ''Agrobacterium tumefaciens''<br />
-
**[[3wi7]] – AtHDH – ''Agrobacterium tumefaciens''<br />
+
**[[3wib]] – AtHLD DatA (mutant) <br />
-
**[[3wib]] – AtHHDH (mutant)<br />
+
**[[2xt0]] – HLD DppA – ''Plesiocystis pacifica'' <br />
-
*''Haloalkane dehalogenase complex with halide ion''
+
*Haloalkane dehalogenase from ''Rhodococcus rhodochrous'' DhaA
-
**[[1edb]], [[1edd]], [[2eda]], [[2edc]], [[2dhe]], [[1b6g]] – XaHDH + halide<br />
+
**[[5flk]], [[2v9z]] – RrHLD DhaA (mutant) <br />
-
**[[1cij]] – XaHDH (mutant) + Br<br />
+
**[[4hzg]] – RrHLD DhaA + Cl<br />
-
**[[1d07]], [[1iz7]], [[1k5p]], [[1mj5]] – SpHDH + halide <br />
+
**[[3rk4]], [[3fbw]], [[3fwh]], [[3g9x]], [[3sk0]], [[4wcv]] – RrHLD DhaA (mutant) + Cl<br />
-
**[[3fbw]], [[1cqw]], [[4hzg]] – RrHDH + halide <br />
+
**[[4fwb]] – RrHLD DhaA (mutant) + trichloropropane<br />
-
**[[3a2m]], [[3a2n]], [[3afi]] – BjHDH + Cl – ''Bradyrhizobium japonicum''<br />
+
-
**[[3a2l]] – BjHDH (mutant) + Cl <br />
+
-
**[[5lka]] – BjHDH (mutant) <br />
+
-
**[[4k2a]] – HDH + Cl – ''Bradyrhizobium elkanii''<br />
+
-
**[[3rk4]], [[3sk0]], [[4f5z]], [[4f60]] – RrHDH (mutant) + halide <br />
+
-
**[[4h7e]], [[4h7f]], [[4h7h]], [[4h7i]], [[4h7j]] [[4h7k]] – SphHDH (mutant) + halide <br />
+
-
**[[4brz]] – RhHDH + Cl - ''Rhodobacteraceae''<br />
+
-
**[[4mj3]] – HDH + Cl – ''Mycobacterium rhodesiae''<br />
+
-
**[[3u1t]] – HDH + Cl – unidentified<br />
+
-
*''Haloalkane dehalogenase other complexes''
+
*Haloalkane dehalogenase from ''Sphingomonas paucimobolis'' LinB
-
**[[2dhc]] – XaHDH + ethylene dichloride<br />
+
**[[1cv2]] – SpHLD LinB <br />
-
**[[2dhd]] – XaHDH + amono-chloroethoxy-oxobutanoic acid + Cl<br />
+
**[[5lka]] – SpHLD LinB (mutant) <br />
-
**[[1g42]] – SpHDH + dichloropropane + Cl<br />
+
**[[1k5p]], [[1mj5]], [[4h77]], [[1iz7]], [[2bfn]], [[1g4h]] – SpHLD LinB + Cl<br />
-
**[[2bfn]] – SpHDH + dichloropropanol + Cl<br />
+
**[[4h7d]], [[4h7e]], [[4h7f]], [[4h7h]], [[4h7i]], [[4h7j]], [[4h7k]], [[4wdq]], [[4wdr]] – SpHLD LinB (mutant) + Cl<br />
-
**[[1g4h]] – SpHDH (mutant) + butanol + Cl<br />
+
**[[1k6e]] – SpHLD LinB + Cl + Br<br />
-
**[[1g5f]] – SpHDH + dichloroethane + Cl<br />
+
**[[1k63]] – SpHLD LinB + Br-propanol<br />
-
**[[1iz8]] – SpHDH + propanediol + Cl<br />
+
**[1d07]], [[1iz8]] – SpHLD LinB + Br<br />
-
**[[4c6h]] – RhHDH + hexanol + Cl<br />
+
**[[1g42]] – SpHLD LinB + trichloropropane<br />
-
**[[3fwh]], [[3g9x]], [[4e46]] – RrHDH + isopropanol + Cl <br />
+
**[[1g5f]] – SpHLD LinB + trichloroethane<br />
-
**[[1k6e]] – SpHDH + bromopropanol + Cl + Br<br />
+
 
-
**[[1k63]] – SpHDH + bromopropene-1-ol + Cl + Br<br />
+
*Haloalkane dehalogenase complex with halogen
-
**[[4fwb]] – SpHDH (mutant) + trichloropropane + Cl<br />
+
 
-
**[[2o2h]] – MtHDH 3 + dichloroethane + Cl – ''Mycobacterium tuberculosis''<br />
+
**[[2dhc]] – XaHLD + dichloroethane<br />
-
**[[2o2i]] – MtHDH 3 + propanediol + Br<br />
+
**[[2dhd]] – XaHLD + chloroethoxy oxobutanoic acid<br />
-
**[[2qvb]] – MtHDH 3 + ethanediol + Cl<br />
+
**[[2dhe]], [[1edd]] – XaHLD + Cl<br />
 +
**[[2eda]], [[2edc]] – XaHLD + I<br />
 +
**[[4mj3]] – HLD DmrA + Cl – ''Mycobacterium rhodesiae''<br />
 +
**[[2qvb]] – MtHLD 3 + Cl – ''Mycobacterium tuberculosis''<br />
 +
**[[2o2h]] – MtHLD 3 + dichloroethane<br />
 +
**[2o2i]] – MtHLD 3 + Br<br />
 +
**[[1b6g]] – XaHLD + Cl <br />
 +
**[[1cij]] – XaHLD + Br <br />
 +
**[[1cqw]] – RrHLD + I<br />
 +
**[[5uxz]], [[5y2y]], [[5vnp]] – RrHLD + Cl + fluorogenic ligand<br />
 +
**[[5uy1]] – RrHLD + Cl<br />
 +
**[[4f5z]] – RrHLD (mutant) + Cl<br />
 +
**[[4f60]] – RrHLD (mutant) + F<br />
 +
**[[4brz]] – RbHLD + Cl <br />
 +
**[[4k2a]] – HLD DbeA + Cl – ''Bradyrhizobium elkanii''<br />
 +
**[[3a2m]], [[3a2n]], [[3afi]] – BjHLD DbjA + Cl – ''Bradyrhizobium japonicum''<br />
 +
**[[3a2l]] – BjHLD DbjA (mutant) + Cl <br />
 +
**[[5esr]] – HLD DccA + Cl – ''Caulobacter crescentus''<br />
*Fluoroacetate dehalogenase (FDH)
*Fluoroacetate dehalogenase (FDH)

Revision as of 11:34, 16 January 2018

Structure of haloalkane dehalogenase complex with I- ion (purple) (PDB code 2edc).

Drag the structure with the mouse to rotate

3D structures of dehalogenase

Updated on 16-January-2018


References

  1. ↑ Koudelakova T, Chovancova E, Brezovsky J, Monincova M, Fortova A, Jarkovsky J, Damborsky J. Substrate specificity of haloalkane dehalogenases. Biochem J. 2011 Apr 15;435(2):345-54. doi: 10.1042/BJ20101405. PMID:21294712 doi:http://dx.doi.org/10.1042/BJ20101405
  2. ↑ Verschueren KH, Kingma J, Rozeboom HJ, Kalk KH, Janssen DB, Dijkstra BW. Crystallographic and fluorescence studies of the interaction of haloalkane dehalogenase with halide ions. Studies with halide compounds reveal a halide binding site in the active site. Biochemistry. 1993 Sep 7;32(35):9031-7. PMID:8369276

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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