5l27

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l27 OCA], [http://pdbe.org/5l27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l27 RCSB], [http://www.ebi.ac.uk/pdbsum/5l27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l27 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l27 OCA], [http://pdbe.org/5l27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l27 RCSB], [http://www.ebi.ac.uk/pdbsum/5l27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l27 ProSAT]</span></td></tr>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Membrane transporters move substrates across the membrane by alternating access of their binding sites between the opposite sides of the membrane. An emerging model of this process is the elevator mechanism, in which a substrate-binding transport domain moves a large distance across the membrane. This mechanism has been characterized by a transition between two states, but the conformational path that leads to the transition is not yet known, largely because the available structural information has been limited to the two end states. Here we present crystal structures of the inward-facing, intermediate, and outward-facing states of a concentrative nucleoside transporter from Neisseria wadsworthii. Notably, we determined the structures of multiple intermediate conformations, in which the transport domain is captured halfway through its elevator motion. Our structures present a trajectory of the conformational transition in the elevator model, revealing multiple intermediate steps and state-dependent conformational changes within the transport domain that are associated with the elevator-like motion.
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Visualizing multistep elevator-like transitions of a nucleoside transporter.,Hirschi M, Johnson ZL, Lee SY Nature. 2017 Apr 17. doi: 10.1038/nature22057. PMID:28424521<ref>PMID:28424521</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5l27" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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</StructureSection>
</StructureSection>

Revision as of 06:25, 4 May 2017

Structure of CNTnw N149L in the intermediate 1 state

5l27, resolution 4.10Å

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