1ufp

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[[Image:1ufp.jpg|left|200px]]
[[Image:1ufp.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1ufp", creates the "Structure Box" on the page.
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{{STRUCTURE_1ufp| PDB=1ufp | SCENE= }}
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|RELATEDENTRY=[[1ufj|1UFJ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ufp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ufp OCA], [http://www.ebi.ac.uk/pdbsum/1ufp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ufp RCSB]</span>
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'''Crystal Structure of an Artificial Metalloprotein:Fe(III)(3,3'-Me2-salophen)/apo-wild type Myoglobin'''
'''Crystal Structure of an Artificial Metalloprotein:Fe(III)(3,3'-Me2-salophen)/apo-wild type Myoglobin'''
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[[Category: Watanabe, Y.]]
[[Category: Watanabe, Y.]]
[[Category: Yamane, T.]]
[[Category: Yamane, T.]]
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[[Category: iron]]
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[[Category: Iron]]
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[[Category: metalloprotein]]
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[[Category: Metalloprotein]]
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[[Category: myoglobin]]
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[[Category: Myoglobin]]
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[[Category: salophen]]
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[[Category: Salophen]]
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[[Category: schiff base]]
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[[Category: Schiff base]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:09:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:09:39 2008''
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Revision as of 08:09, 3 May 2008

Image:1ufp.jpg

Template:STRUCTURE 1ufp

Crystal Structure of an Artificial Metalloprotein:Fe(III)(3,3'-Me2-salophen)/apo-wild type Myoglobin


Overview

Apo-myoglobin (apo-Mb) and apo-A71GMb were successfully reconstituted with FeIII(salophen) (1) (salophen = N,N'-bis(salicylidene)-1,2-phenilenediamine), Fe(III)(3,3'-Me2-salophen) (2), and FeIII(5,5'-t-Bu2-salophen) (3). The crystal structure of 2.apo-A71GMb shows the tight binding of the complex in the Mb cavity, while in wild-type apo-Mb it is highly disordered due to the steric repulsion with Ala71. Furthermore, the structure of 2.apo-A71GMb suggests a possible accommodation of a small substrate in the cavity. In fact, the cyanide association rate constant of 2.apo-A71GMb is 216-fold larger compared to that of 2.apo-Mb. These results provide us principles for the noncovalent fixation of synthetic metal cofactors at the desired positions in protein matrixes.

About this Structure

1UFP is a Single protein structure of sequence from Physeter catodon. Full crystallographic information is available from OCA.

Reference

Crystal structures of artificial metalloproteins: tight binding of FeIII(Schiff-Base) by mutation of Ala71 to Gly in apo-myoglobin., Ueno T, Ohashi M, Kono M, Kondo K, Suzuki A, Yamane T, Watanabe Y, Inorg Chem. 2004 May 3;43(9):2852-8. PMID:15106972 Page seeded by OCA on Sat May 3 11:09:32 2008

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