Dehydroquinase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The structure of dehydroquinase type I complex with quinate shows <scene name='55/553960/Cv/ | + | The structure of dehydroquinase type I complex with quinate shows <scene name='55/553960/Cv/10'>DHQD as a homodimer</scene>. The binding of quinate in <scene name='55/553960/Cv/11'>monomer A is slightly different than in monomer B</scene>.<ref>PMID:24437575</ref> <scene name='55/553960/Cv/12'>Click here to see the animation of this scene</scene>. |
</StructureSection> | </StructureSection> | ||
Revision as of 10:59, 21 February 2019
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3D structures of dehydroquinase
Updated on 21-February-2019
References
- ↑ Herrmann KM. The Shikimate Pathway: Early Steps in the Biosynthesis of Aromatic Compounds. Plant Cell. 1995 Jul;7(7):907-919. PMID:12242393 doi:http://dx.doi.org/10.1105/tpc.7.7.907
- ↑ Dias MV, Snee WC, Bromfield KM, Payne R, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. Biochem J. 2011 Mar 17. PMID:21410435 doi:10.1042/BJ20110002
- ↑ Light SH, Antanasijevic A, Krishna SN, Caffrey M, Anderson WF, Lavie A. Crystal structures of type I dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of Schiff base formation. Biochemistry. 2014 Feb 11;53(5):872-80. doi: 10.1021/bi4015506. Epub 2014 Jan 31. PMID:24437575 doi:http://dx.doi.org/10.1021/bi4015506
