5nnj

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m (Protected "5nnj" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5nnj is ON HOLD
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==Dimer structure of Sortilin ectodomain crystal form 3, 4.0 Angstrom==
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<StructureSection load='5nnj' size='340' side='right' caption='[[5nnj]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5nnj]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NNJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NNJ FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnj OCA], [http://pdbe.org/5nnj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nnj RCSB], [http://www.ebi.ac.uk/pdbsum/5nnj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SORT_MOUSE SORT_MOUSE]] Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.<ref>PMID:10594043</ref> <ref>PMID:15236332</ref> <ref>PMID:15236333</ref> <ref>PMID:15372498</ref> <ref>PMID:15992544</ref> <ref>PMID:19407813</ref> <ref>PMID:21102451</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Janssen, B J.C]]
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[[Category: Leloup, N O.L]]
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[[Category: Transport protein]]
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[[Category: Transport receptor]]
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[[Category: Vps10 domain]]

Revision as of 06:07, 29 November 2017

Dimer structure of Sortilin ectodomain crystal form 3, 4.0 Angstrom

5nnj, resolution 4.00Å

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