This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5nnu
From Proteopedia
(Difference between revisions)
m (Protected "5nnu" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==KSHV uracil-DNA glycosylase, product complex with dsDNA exhibiting duplex nucleotide flipping== | |
| - | + | <StructureSection load='5nnu' size='340' side='right' caption='[[5nnu]], [[Resolution|resolution]] 2.97Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5nnu]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NNU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AAB:2-DEOXY-RIBOFURANOSE-5-MONOPHOSPHATE'>AAB</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5nnh|5nnh]], [[5nn7|5nn7]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uracil-DNA_glycosylase Uracil-DNA glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.27 3.2.2.27] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnu OCA], [http://pdbe.org/5nnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nnu RCSB], [http://www.ebi.ac.uk/pdbsum/5nnu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnu ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q76RG8_HHV8 Q76RG8_HHV8]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.[HAMAP-Rule:MF_04046] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Uracil-DNA glycosylase]] | ||
| + | [[Category: Bagneris, C]] | ||
| + | [[Category: Barrett, T]] | ||
| + | [[Category: Earl, C]] | ||
| + | [[Category: Savva, R]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Uracil-dna glycosylase]] | ||
Revision as of 07:30, 21 March 2018
KSHV uracil-DNA glycosylase, product complex with dsDNA exhibiting duplex nucleotide flipping
| |||||||||||
