1ujl
From Proteopedia
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[[Image:1ujl.gif|left|200px]] | [[Image:1ujl.gif|left|200px]] | ||
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'''Solution Structure of the HERG K+ channel S5-P extracellular linker''' | '''Solution Structure of the HERG K+ channel S5-P extracellular linker''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1UJL is a [[Single protein]] structure | + | 1UJL is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJL OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Torres, A M.]] | [[Category: Torres, A M.]] | ||
[[Category: Vandenberg, J I.]] | [[Category: Vandenberg, J I.]] | ||
| - | [[Category: | + | [[Category: Amphiphatic helix]] |
| - | [[Category: | + | [[Category: Two helice]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:18:45 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:18, 3 May 2008
Solution Structure of the HERG K+ channel S5-P extracellular linker
Overview
The HERG K+ channel has very unusual kinetic behaviour that includes slow activation but rapid inactivation. These features are critical for normal cardiac repolarisation as well as in preventing lethal ventricular arrhythmias. Extensive mutagenesis of the HERG K+ channel has allowed identification of which regions of the channel are important for the unusual kinetic behaviour of the channel. Furthermore, structural studies on scorpion toxins that potently inhibit HERG are beginning to provide clues as to the structural differences between HERG and other voltage-gated K+ channels.
About this Structure
1UJL is a Single protein structure. Full crystallographic information is available from OCA.
Reference
The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics., Vandenberg JI, Torres AM, Campbell TJ, Kuchel PW, Eur Biophys J. 2004 Apr;33(2):89-97. Epub 2003 Sep 10. PMID:13680209 Page seeded by OCA on Sat May 3 11:18:45 2008
