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1um0

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[[Image:1um0.jpg|left|200px]]
[[Image:1um0.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1um0 |SIZE=350|CAPTION= <scene name='initialview01'>1um0</scene>, resolution 1.95&Aring;
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The line below this paragraph, containing "STRUCTURE_1um0", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Chorismate_synthase Chorismate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.5 4.2.3.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= AROC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])
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-->
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|DOMAIN=
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{{STRUCTURE_1um0| PDB=1um0 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1um0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1um0 OCA], [http://www.ebi.ac.uk/pdbsum/1um0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1um0 RCSB]</span>
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}}
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'''Crystal structure of chorismate synthase complexed with FMN'''
'''Crystal structure of chorismate synthase complexed with FMN'''
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[[Category: Suh, S W.]]
[[Category: Suh, S W.]]
[[Category: Yoon, H J.]]
[[Category: Yoon, H J.]]
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[[Category: beta-alpha-beta sandwich fold]]
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[[Category: Beta-alpha-beta sandwich fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:24:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:12:09 2008''
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Revision as of 08:24, 3 May 2008

Image:1um0.jpg

Template:STRUCTURE 1um0

Crystal structure of chorismate synthase complexed with FMN


Overview

Chorismate synthase catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate to chorismate in the shikimate pathway, which represents an attractive target for discovering antimicrobial agents and herbicides. Chorismate serves as a common precursor for the synthesis of aromatic amino acids and many aromatic compounds in microorganisms and plants. Chorismate synthase requires reduced FMN as a cofactor but the catalyzed reaction involves no net redox change. Here, we have determined the crystal structure of chorismate synthase from Helicobacter pylori in both FMN-bound and FMN-free forms. It is a tetrameric enzyme, with each monomer possessing a novel "beta-alpha-beta sandwich fold". Highly conserved regions, including several flexible loops, cluster together around the bound FMN to form the active site. The unique FMN-binding site is formed largely by a single subunit, with a small contribution from a neighboring subunit. The isoalloxazine ring of the bound FMN is significantly non-planar. Our structure illuminates the essential functional roles played by the cofactor.

About this Structure

1UM0 is a Single protein structure of sequence from Helicobacter pylori. Full crystallographic information is available from OCA.

Reference

Crystal structure of chorismate synthase: a novel FMN-binding protein fold and functional insights., Ahn HJ, Yoon HJ, Lee B 2nd, Suh SW, J Mol Biol. 2004 Feb 27;336(4):903-15. PMID:15095868 Page seeded by OCA on Sat May 3 11:24:39 2008

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