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1uoc

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[[Image:1uoc.gif|left|200px]]
[[Image:1uoc.gif|left|200px]]
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{{Structure
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|PDB= 1uoc |SIZE=350|CAPTION= <scene name='initialview01'>1uoc</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1uoc", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Environment+For+Xe+In+Chain+B'>AC1</scene>
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=XE:XENON'>XE</scene>
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{{STRUCTURE_1uoc| PDB=1uoc | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uoc OCA], [http://www.ebi.ac.uk/pdbsum/1uoc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uoc RCSB]</span>
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'''X-RAY STRUCTURE OF THE RNASE DOMAIN OF THE YEAST POP2 PROTEIN'''
'''X-RAY STRUCTURE OF THE RNASE DOMAIN OF THE YEAST POP2 PROTEIN'''
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[[Category: Suck, D.]]
[[Category: Suck, D.]]
[[Category: Thore, S.]]
[[Category: Thore, S.]]
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[[Category: dedd nuclease]]
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[[Category: Dedd nuclease]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: mrna degradation]]
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[[Category: Mrna degradation]]
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[[Category: phosphorylation.]]
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[[Category: Phosphorylation.]]
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[[Category: poly(a) tail]]
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[[Category: Repressor]]
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[[Category: repressor]]
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[[Category: Transcription regulation]]
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[[Category: transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:29:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:13:03 2008''
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Revision as of 08:29, 3 May 2008

Image:1uoc.gif

Template:STRUCTURE 1uoc

X-RAY STRUCTURE OF THE RNASE DOMAIN OF THE YEAST POP2 PROTEIN


Overview

In Saccharomyces cerevisiae, a large complex, known as the Ccr4-Not complex, containing two nucleases, is responsible for mRNA deadenylation. One of these nucleases is called Pop2 and has been identified by similarity with PARN, a human poly(A) nuclease. Here, we present the crystal structure of the nuclease domain of Pop2 at 2.3 A resolution. The domain has the fold of the DnaQ family and represents the first structure of an RNase from the DEDD superfamily. Despite the presence of two non-canonical residues in the active site, the domain displays RNase activity on a broad range of RNA substrates. Site-directed mutagenesis of active-site residues demonstrates the intrinsic ability of the Pop2 RNase D domain to digest RNA. This first structure of a nuclease involved in the 3'-5' deadenylation of mRNA in yeast provides information for the understanding of the mechanism by which the Ccr4-Not complex achieves its functions.

About this Structure

1UOC is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

X-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complex., Thore S, Mauxion F, Seraphin B, Suck D, EMBO Rep. 2003 Dec;4(12):1150-5. Epub 2003 Nov 14. PMID:14618157 Page seeded by OCA on Sat May 3 11:29:43 2008

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