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DNA damage-binding protein

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*DDB1
*DDB1
-
**[[2b5l]] – hDDB + simian virus 5 protein – human<br />
+
**[[3e0c]] – hDDB - human<br />
-
**[[2b5m]] – hDDB <br />
+
**[[2b5m]], [[2b5n]] – hDDB BPB domain<br />
**[[2b5m]], [[2b5n]] – hDDB BPB domain<br />
-
**[[2hye]] – hDDB + simian virus 5 protein + cullin-4A + ring-box protein 1<br />
+
 
-
**[[3e0c]] – hDDB <br />
+
*DDB1 binary complex
-
**[[3i7h]], [[3i7k]], [[3i7l]], [[3i7n]], [[3i7o]], [[3i7p]], [[3i89]], [[3i8c]], [[3i8e]] – hDDB + X protein peptide<br />
+
 
-
**[[4a11]] – hDDB + DNA excision repair protein ERCC-8<br />
+
**[[2b5l]] – hDDB + simian virus 5 protein <br />
 +
**[[3i7h]], [[3i7k]], [[3i7l]], [[3i7n]], [[3i7o]], [[3i7p]], [[3i89]], [[3i8c]], **[[3i8e]] – hDDB + X protein peptide<br />
 +
**[[6dsz]] – hDDB + DET1 peptide<br />
 +
**[[4a11]], [[6fcv]] – hDDB + DNA excision repair protein ERCC-8<br />
 +
 
 +
*DDB1 ternary complex
 +
 
**[[4ci1]], [[4ci2]], [[4ci3]], [[4tz4]] – hDDB + cereblon + thalidomide derivative<br />
**[[4ci1]], [[4ci2]], [[4ci3]], [[4tz4]] – hDDB + cereblon + thalidomide derivative<br />
 +
**[[5v3o]] – hDDB + cereblon + piperidine derivative<br />
**[[5fqd]] – hDDB + cereblon + casein kinase 1<br />
**[[5fqd]] – hDDB + cereblon + casein kinase 1<br />
**[[5hxb]] – hDDB + cereblon + ERF3A<br />
**[[5hxb]] – hDDB + cereblon + ERF3A<br />
 +
**[[6bn8]], [[6bn9]], [[6bnb]], [[6boy]] – hDDB + cereblon + BRD4<br />
 +
**[[6h0f]] – hDDB (mutant) + cereblon + IKAROS<br />
 +
**[[6h0g]] – hDDB (mutant) + cereblon + ZNF692<br />
 +
**[[6td3]] – hDDB + cyclin-dependent kinase 12 + cyclin-K<br />
 +
 +
*DDB1 quaternary complex
 +
 +
**[[6uml]] – hDDB + cereblon + ZNF797 + thalidomide derivative <br />
 +
**[[2hye]] – hDDB + simian virus 5 protein + cullin-4A + ring-box protein 1<br />
 +
**[[6pai]], [[6q0r]], [[6ue5]] – hDDB + DDA1 + RNA-binding protein 39 + DET1 + sulfonamide derivative<br />
 +
**[[6q0v]], [[6q0w]], [[6ud7]] – hDDB + DDA1 + RNA-binding protein 39 + DET1 + anti-cancer drug<br />
 +
**[[6sj7]] – hDDB + DDA1 + RNA-binding protein 39 + DET1 + anti-cancer drug – Cryo EM<br />
**[[5jk7]] – hDDB + VPRBP + uracil-DNA glycosylase + VPR<br />
**[[5jk7]] – hDDB + VPRBP + uracil-DNA glycosylase + VPR<br />
*DDB1+DDB2
*DDB1+DDB2
-
**[[3ei1]], [[3ei2]], [[4a08]], [[4a09]], [[4a0a]], [[4a0b]], [[4e54]], [[4e5z]] – hDDB + DNA<br />
 
**[[3ei3]], [[3ei4]] – hDDB <br />
**[[3ei3]], [[3ei4]] – hDDB <br />
 +
**[[3ei1]], [[3ei2]], [[4a08]], [[4a09]], [[4a0a]], [[4a0b]], [[4e54]], [[4e5z]] – hDDB + DNA<br />
**[[4a0k]] – hDDB + cullin-4A + ring-box protein 1<br />
**[[4a0k]] – hDDB + cullin-4A + ring-box protein 1<br />
**[[4a0l]] – hDDB + cullin-4A + ring-box protein 1 + DNA<br />
**[[4a0l]] – hDDB + cullin-4A + ring-box protein 1 + DNA<br />
 +
**[[6r8y]], [[6r8z]], [[6r90]], [[6r91]], [[6r92]] – hDDB + histones + DNA – Cryo EM<br />
 +
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:26, 16 July 2020

Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code 3ei1).

Drag the structure with the mouse to rotate

3D Structures of DNA damage-binding protein

Updated on 16-July-2020

References

  1. ↑ Guerrero-Santoro J, Kapetanaki MG, Hsieh CL, Gorbachinsky I, Levine AS, Rapic-Otrin V. The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A. Cancer Res. 2008 Jul 1;68(13):5014-22. PMID:18593899 doi:68/13/5014

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Michal Harel, Alexander Berchansky

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