Disintegrin
From Proteopedia
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<StructureSection load='1z1x' size='350' side='right' scene='Disintegrin/Cv/1' caption='Disintegrin, [[1z1x]]'> | <StructureSection load='1z1x' size='350' side='right' scene='Disintegrin/Cv/1' caption='Disintegrin, [[1z1x]]'> | ||
| + | == Function == | ||
[[Disintegrin|Disintegrins]] are a family of cysteine-rich toxins from viper venoms which inhibit platelet aggregation and cell adhesion. <ref>PMID:15578957</ref> Over 100 disintegrins have been studied. | [[Disintegrin|Disintegrins]] are a family of cysteine-rich toxins from viper venoms which inhibit platelet aggregation and cell adhesion. <ref>PMID:15578957</ref> Over 100 disintegrins have been studied. | ||
| + | == Relevance == | ||
Disintegrins which have anti-integrin activity, have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer. Disintegrin also functions in inhibition of adipogenesis<ref>PMID:18508683</ref>. | Disintegrins which have anti-integrin activity, have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer. Disintegrin also functions in inhibition of adipogenesis<ref>PMID:18508683</ref>. | ||
Revision as of 08:51, 24 April 2017
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3D Structures of Disintegrin
Updated on 24-April-2017
2w9o, 2w9u, 2w9v, 2w9w – jerdostatin residues 68-110 – Trimeresurus jerdonii – NMR
1j2l – trimestatin - Trimeresurus flavovidrius
2pjf, 1q7i, 1q7j, 1n4y – Cr rhodostoxin residues 1-68 – Calloselasma rhodostoma – NMR
2pjg, 2pji, 2ljv - Cr rhodostoxin (mutant) – NMR
3uci - Cr rhodostoxin (mutant)
4rqg – Cr rhodostomin
4r5r, 4r5u – Cr rhodostomin (mutant)
1z1x, 1tej – Ec disintegrin – Echis carinatus
1rmr – Ec schistatin
1ro3, 2ech – Ec echistatin - NMR
1l3x – salmosin – Gloydius brevicaudus – NMR
1mpz – obtustatin – Macrovipera obtusa - NMR
3c05 – acostatin-α residues 48-109+acostatin-β residues 419-482 – copperhead
3dsl – bothropasin - Jararaca
2dw0, 2dw1, 2dw2 – catrocollastatin – rattlesnake
2mop, 2mp5 – bitistatin – African puff adder - NMR
Dendrotoxin
References
- ↑ McLane MA, Sanchez EE, Wong A, Paquette-Straub C, Perez JC. Disintegrins. Curr Drug Targets Cardiovasc Haematol Disord. 2004 Dec;4(4):327-55. PMID:15578957
- ↑ McLane MA, Joerger T, Mahmoud A. Disintegrins in health and disease. Front Biosci. 2008 May 1;13:6617-37. PMID:18508683
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