Pantothenate synthetase
From Proteopedia
(Difference between revisions)
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**[[3mue]] - PS – ''Salmonella typhimurium''<br /> | **[[3mue]] - PS – ''Salmonella typhimurium''<br /> | ||
**[[3mxt]] - CjPS – ''Campylobacter jejuni''<br /> | **[[3mxt]] - CjPS – ''Campylobacter jejuni''<br /> | ||
| - | **[[3ag5]] - SaPS – ''Staphylococcus aureus'' | + | **[[3ag5]] - SaPS – ''Staphylococcus aureus''<br /> |
| + | **[[5hg0]] - FtPS + SAM – ''Francisella tularensis''<br /> | ||
| - | *Pantothenate synthetase | + | *Pantothenate synthetase complex with adenosine derivatives |
**[[1n2g]] - MtPS + AMPCPP <br /> | **[[1n2g]] - MtPS + AMPCPP <br /> | ||
**[[2a7x]] - MtPS (mutant) + AMP<br /> | **[[2a7x]] - MtPS (mutant) + AMP<br /> | ||
| - | **[[3n8h]] - FtPS + AMP | + | **[[3n8h]] - FtPS + AMP <br /> |
**[[3q10]] - YpPS + AMP – ''Yersinia pestis''<br /> | **[[3q10]] - YpPS + AMP – ''Yersinia pestis''<br /> | ||
**[[3uk2]] - PS + AMP – ''Burkholderia thailandesis''<br /> | **[[3uk2]] - PS + AMP – ''Burkholderia thailandesis''<br /> | ||
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**[[2x3f]] - SaPS + ATP derivative<br /> | **[[2x3f]] - SaPS + ATP derivative<br /> | ||
**[[3inn]] - PS + ATP – ''Brucella melitensis''<br /> | **[[3inn]] - PS + ATP – ''Brucella melitensis''<br /> | ||
| - | **[[3iob]], [[3ioc]], [[3iod]], [[3ioe]] - MtPS (mutant) + adenosine derivative | + | **[[3iob]], [[3ioc]], [[3iod]], [[3ioe]] - MtPS (mutant) + adenosine derivative<br /> |
| + | **[[5kwv]] – NgPS (mutant) + AMPPNP – ''Neisseria gonorrhoeae''<br /> | ||
| + | **[[5ucr]] – NgPS (mutant) + AMP + alanine<br /> | ||
*Pantothenate synthetase binary complex with pantoate derivatives | *Pantothenate synthetase binary complex with pantoate derivatives | ||
Revision as of 10:16, 29 August 2017
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3D structures of pantothenate synthetase
Updated on 29-August-2017
References
- ↑ Jonczyk R, Ronconi S, Rychlik M, Genschel U. Pantothenate synthetase is essential but not limiting for pantothenate biosynthesis in Arabidopsis. Plant Mol Biol. 2008 Jan;66(1-2):1-14. Epub 2007 Oct 12. PMID:17932772 doi:http://dx.doi.org/10.1007/s11103-007-9248-6
- ↑ Hung AW, Silvestre HL, Wen S, George GP, Boland J, Blundell TL, Ciulli A, Abell C. Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis. ChemMedChem. 2016 Jan 5;11(1):38-42. doi: 10.1002/cmdc.201500414. Epub 2015 Oct, 21. PMID:26486566 doi:http://dx.doi.org/10.1002/cmdc.201500414
- ↑ Wang S, Eisenberg D. Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate. Protein Sci. 2003 May;12(5):1097-108. PMID:12717031
