1uqr

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[[Image:1uqr.gif|left|200px]]
[[Image:1uqr.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1uqr |SIZE=350|CAPTION= <scene name='initialview01'>1uqr</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1uqr", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Trs+Binding+Site+For+Chain+K'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1uqr| PDB=1uqr | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uqr OCA], [http://www.ebi.ac.uk/pdbsum/1uqr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uqr RCSB]</span>
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}}
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'''TYPE II 3-DEHYDROQUINATE DEHYDRATASE (DHQASE) FROM ACTINOBACILLUS PLEUROPNEUMONIAE'''
'''TYPE II 3-DEHYDROQUINATE DEHYDRATASE (DHQASE) FROM ACTINOBACILLUS PLEUROPNEUMONIAE'''
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[[Category: Yu, B.]]
[[Category: Yu, B.]]
[[Category: Zegers, I.]]
[[Category: Zegers, I.]]
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[[Category: aromatic amino acid biosynthesis]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: shikimate pathway]]
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[[Category: Shikimate pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:33:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:13:49 2008''
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Revision as of 08:33, 3 May 2008

Image:1uqr.gif

Template:STRUCTURE 1uqr

TYPE II 3-DEHYDROQUINATE DEHYDRATASE (DHQASE) FROM ACTINOBACILLUS PLEUROPNEUMONIAE


Overview

The structure of the type II dehydroquinate dehydratase (DHQase) from Actinobacillus pleuropneumoniae, the third enzyme of the shikimate pathway, has been determined. Crystals diffracting to 1.7 A were obtained in space and on earth using the counter-diffusion technique. The structure was solved using molecular replacement and refined to high resolution. The overall structure of the dodecameric enzyme is described and compared with structures of DHQases from other bacteria. DHQases contain a flexible loop that presumably closes over the active site upon substrate binding. The enzyme can exist in an open or closed conformation. The present structure displays the open conformation, with a sulfate anion bound in the active site. The availability of this structure opens a route to structure-based antibiotics targetting this pathogenic bacterium.

About this Structure

1UQR is a Single protein structure of sequence from Actinobacillus pleuropneumoniae. Full crystallographic information is available from OCA.

Reference

Structural study of the type II 3-dehydroquinate dehydratase from Actinobacillus pleuropneumoniae., Maes D, Gonzalez-Ramirez LA, Lopez-Jaramillo J, Yu B, De Bondt H, Zegers I, Afonina E, Garcia-Ruiz JM, Gulnik S, Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):463-71. Epub 2004, Feb 25. PMID:14993670 Page seeded by OCA on Sat May 3 11:33:39 2008

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