Ornithine carbamoyltransferase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | OTC structure contains an N-terminal - CP-binding domain and a C-terminal - ornithine binding domain. OCT active site is situated between the two domains<ref>PMID:18062991</ref>. | + | The biological assembly of OTC is <scene name='57/573976/Cv/2'>homotrimer</scene>. OTC structure contains an N-terminal - CP-binding domain and a C-terminal - ornithine binding domain. OCT active site is situated between the two domains<ref>PMID:18062991</ref>. |
</StructureSection> | </StructureSection> | ||
==3D structures of ornithine carbamoyltransferase== | ==3D structures of ornithine carbamoyltransferase== | ||
Revision as of 11:27, 25 April 2017
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3D structures of ornithine carbamoyltransferase
Updated on 25-April-2017
References
- ↑ Murata LB, Schachman HK. Structural similarity between ornithine and aspartate transcarbamoylases of Escherichia coli: characterization of the active site and evidence for an interdomain carboxy-terminal helix in ornithine transcarbamoylase. Protein Sci. 1996 Apr;5(4):709-18. PMID:8845761 doi:http://dx.doi.org/10.1002/pro.5560050416
- ↑ Storkanova G, Vlaskova H, Chuzhanova N, Zeman J, Stranecky V, Majer F, Peskova K, Luksan O, Jirsa M, Hrebicek M, Dvorakova L. Ornithine carbamoyltransferase deficiency: molecular characterization of 29 families. Clin Genet. 2013 Dec;84(6):552-9. doi: 10.1111/cge.12085. Epub 2013 Feb 7. PMID:23278509 doi:http://dx.doi.org/10.1111/cge.12085
- ↑ Sankaranarayanan R, Cherney MM, Cherney LT, Garen CR, Moradian F, James MN. The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism. J Mol Biol. 2008 Jan 25;375(4):1052-63. Epub 2007 Nov 19. PMID:18062991 doi:10.1016/j.jmb.2007.11.025
