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1urn
From Proteopedia
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[[Image:1urn.jpg|left|200px]] | [[Image:1urn.jpg|left|200px]] | ||
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'''U1A MUTANT/RNA COMPLEX + GLYCEROL''' | '''U1A MUTANT/RNA COMPLEX + GLYCEROL''' | ||
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[[Category: Oubridge, C.]] | [[Category: Oubridge, C.]] | ||
[[Category: Teo, C H.]] | [[Category: Teo, C H.]] | ||
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| - | [[Category: | + | [[Category: Protein-rna complex]] |
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:35:44 2008'' | |
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Revision as of 08:35, 3 May 2008
U1A MUTANT/RNA COMPLEX + GLYCEROL
Overview
The crystal structure of the RNA-binding domain of the small nuclear ribonucleoprotein U1A bound to a 21-nucleotide RNA hairpin has been determined at 1.92 A resolution. The ten-nucleotide RNA loop binds to the surface of the beta-sheet as an open structure, and the AUUGCAC sequence of the loop interacts extensively with the conserved RNP1 and RNP2 motifs and the C-terminal extension of the RNP domain. These interactions include stacking of RNA bases with aromatic side chains of proteins and many direct and water-mediated hydrogen bonds. The structure reveals the stereochemical basis for sequence-specific RNA recognition by the RNP domain.
About this Structure
1URN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin., Oubridge C, Ito N, Evans PR, Teo CH, Nagai K, Nature. 1994 Dec 1;372(6505):432-8. PMID:7984237 Page seeded by OCA on Sat May 3 11:35:44 2008
