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1urj

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[[Image:1urj.gif|left|200px]]
[[Image:1urj.gif|left|200px]]
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{{Structure
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|PDB= 1urj |SIZE=350|CAPTION= <scene name='initialview01'>1urj</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1urj", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Hg+Binding+Site+For+Chain+B'>AC1</scene>
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|LIGAND= <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_1urj| PDB=1urj | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1urj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1urj OCA], [http://www.ebi.ac.uk/pdbsum/1urj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1urj RCSB]</span>
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}}
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'''SINGLE STRANDED DNA-BINDING PROTEIN(ICP8) FROM HERPES SIMPLEX VIRUS-1'''
'''SINGLE STRANDED DNA-BINDING PROTEIN(ICP8) FROM HERPES SIMPLEX VIRUS-1'''
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[[Category: Panjikar, S.]]
[[Category: Panjikar, S.]]
[[Category: Tucker, P A.]]
[[Category: Tucker, P A.]]
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[[Category: dna replication]]
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[[Category: Dna replication]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: hsv-1]]
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[[Category: Hsv-1]]
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[[Category: icp8]]
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[[Category: Icp8]]
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[[Category: nuclear protein.]]
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[[Category: Nuclear protein.]]
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[[Category: ssb]]
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[[Category: Ssb]]
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[[Category: zinc-finger]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:35:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:14:15 2008''
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Revision as of 08:35, 3 May 2008

Image:1urj.gif

Template:STRUCTURE 1urj

SINGLE STRANDED DNA-BINDING PROTEIN(ICP8) FROM HERPES SIMPLEX VIRUS-1


Overview

All organisms including animal viruses use specific proteins to bind single-stranded DNA rapidly in a non-sequence-specific, flexible, and cooperative manner during the DNA replication process. The crystal structure of a 60-residue C-terminal deletion construct of ICP8, the major single-stranded DNA-binding protein from herpes simplex virus-1, was determined at 3.0 A resolution. The structure reveals a novel fold, consisting of a large N-terminal domain (residues 9-1038) and a small C-terminal domain (residues 1049-1129). On the basis of the structure and the nearest neighbor interactions in the crystal, we have presented a model describing the site of single-stranded DNA binding and explaining the basis for cooperative binding. This model agrees with the beaded morphology observed in electron micrographs.

About this Structure

1URJ is a Single protein structure of sequence from Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

The crystal structure of the herpes simplex virus 1 ssDNA-binding protein suggests the structural basis for flexible, cooperative single-stranded DNA binding., Mapelli M, Panjikar S, Tucker PA, J Biol Chem. 2005 Jan 28;280(4):2990-7. Epub 2004 Oct 26. PMID:15507432 Page seeded by OCA on Sat May 3 11:35:37 2008

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