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1ush

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[[Image:1ush.jpg|left|200px]]
[[Image:1ush.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1ush |SIZE=350|CAPTION= <scene name='initialview01'>1ush</scene>, resolution 1.73&Aring;
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The line below this paragraph, containing "STRUCTURE_1ush", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ZNB:Zn+Binding+Site'>ZNB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= USHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1ush| PDB=1ush | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ush FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ush OCA], [http://www.ebi.ac.uk/pdbsum/1ush PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ush RCSB]</span>
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}}
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'''5'-NUCLEOTIDASE FROM E. COLI'''
'''5'-NUCLEOTIDASE FROM E. COLI'''
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[[Category: Knofel, T.]]
[[Category: Knofel, T.]]
[[Category: Strater, N.]]
[[Category: Strater, N.]]
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[[Category: hydrolase (phosphoric monoester)]]
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[[Category: Periplasmic protein]]
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[[Category: periplasmic protein]]
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[[Category: Phosphatase]]
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[[Category: phosphatase]]
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[[Category: Udp-sugar hydrolase]]
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[[Category: udp-sugar hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:37:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:14:33 2008''
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Revision as of 08:37, 3 May 2008

Image:1ush.jpg

Template:STRUCTURE 1ush

5'-NUCLEOTIDASE FROM E. COLI


Overview

The crystal structure of 5'-nucleotidase (5'-NT) from E. coli, also known as UDP-sugar hydrolase, has been determined at 1.7 A resolution. Two zinc ions are present in the active site, which is located in a cleft between two domains. The dimetal center and a catalytic Asp-His dyad are the main players in the catalytic mechanism. Structure-based sequence comparisons show that the structure also provides a model for animal 5'-NTs, which together with other ectonucleotidases terminate the action of nucleotides as extracellular signaling substances in the nervous system.

About this Structure

1USH is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase containing a dimetal catalytic site., Knofel T, Strater N, Nat Struct Biol. 1999 May;6(5):448-53. PMID:10331872 Page seeded by OCA on Sat May 3 11:37:36 2008

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