1h1b
From Proteopedia
(New page: 200px<br /> <applet load="1h1b" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h1b, resolution 2.0Å" /> '''CRYSTAL STRUCTURE OF...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1H1B is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with 151 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H1B OCA]]. | + | 1H1B is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with 151 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Leukocyte_elastase Leukocyte elastase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H1B OCA]]. |
==Reference== | ==Reference== | ||
Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151)., Macdonald SJ, Dowle MD, Harrison LA, Clarke GD, Inglis GG, Johnson MR, Shah P, Smith RA, Amour A, Fleetwood G, Humphreys DC, Molloy CR, Dixon M, Godward RE, Wonacott AJ, Singh OM, Hodgson ST, Hardy GW, J Med Chem. 2002 Aug 29;45(18):3878-90. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12190311 12190311] | Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151)., Macdonald SJ, Dowle MD, Harrison LA, Clarke GD, Inglis GG, Johnson MR, Shah P, Smith RA, Amour A, Fleetwood G, Humphreys DC, Molloy CR, Dixon M, Godward RE, Wonacott AJ, Singh OM, Hodgson ST, Hardy GW, J Med Chem. 2002 Aug 29;45(18):3878-90. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12190311 12190311] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Leukocyte elastase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Amour, A.]] | [[Category: Amour, A.]] | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:08:24 2007'' |
Revision as of 09:03, 30 October 2007
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CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL ELASTASE COMPLEXED WITH AN INHIBITOR (GW475151)
Overview
Described herein is a modern approach to the rapid preparation and, evaluation of compounds as potential back-up drug candidates. GW311616A, 1, a derivative of pyrrolidine trans-lactams, has previously been, described as a potent, orally active inhibitor of human neutrophil, elastase (HNE) for the treatment of respiratory disease. These properties, made it a suitable candidate for development. Described here is the, discovery of three further derivatives of pyrrolidine trans-lactams, which, fulfill the criteria required for back-up candidates 28, 29, and 32. These, include increased activity in inhibiting HNE in human whole blood (HWB), and comparable pharmacokinetic properties, in particular clearance, in two, species. To provide a rapid assessment of clearance, cassette dosing in, dog ... [(full description)]
About this Structure
1H1B is a [Single protein] structure of sequence from [Homo sapiens] with 151 as [ligand]. Active as [Leukocyte elastase], with EC number [3.4.21.37]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151)., Macdonald SJ, Dowle MD, Harrison LA, Clarke GD, Inglis GG, Johnson MR, Shah P, Smith RA, Amour A, Fleetwood G, Humphreys DC, Molloy CR, Dixon M, Godward RE, Wonacott AJ, Singh OM, Hodgson ST, Hardy GW, J Med Chem. 2002 Aug 29;45(18):3878-90. PMID:12190311
Page seeded by OCA on Tue Oct 30 11:08:24 2007
Categories: Homo sapiens | Leukocyte elastase | Single protein | Amour, A. | Clarke, G.D.E. | Dixon, M. | Dowle, M.D. | Fleetwood, G. | Godward, R.E. | Hardy, G.W. | Harrison, L.A. | Hodgson, S.T. | Humphreys, D.C. | Inglis, G.G.A. | Johnson, M.R. | Macdonald, S.J.F. | Molloy, C.R. | Singh, O.M.P. | Smith, R.A. | Wonacott, A.J. | 151 | Hydrolase | Neutrophil elastase | Serine protease
