5un5
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Frizzled-8 complex with designed surrogate Wnt agonist, crystal form 1== | |
| - | + | <StructureSection load='5un5' size='340' side='right' caption='[[5un5]], [[Resolution|resolution]] 2.99Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5un5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UN5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UN5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5un6|5un6]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5un5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5un5 OCA], [http://pdbe.org/5un5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5un5 RCSB], [http://www.ebi.ac.uk/pdbsum/5un5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5un5 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FZD8_HUMAN FZD8_HUMAN]] Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.<ref>PMID:11448771</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Garcia, K C]] | ||
| + | [[Category: Janda, C Y]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Signaling protein-de novo protein complex]] | ||
Revision as of 13:11, 4 May 2017
Frizzled-8 complex with designed surrogate Wnt agonist, crystal form 1
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