1utc
From Proteopedia
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'''CLATHRIN TERMINAL DOMAIN COMPLEXED WITH TLPWDLWTT''' | '''CLATHRIN TERMINAL DOMAIN COMPLEXED WITH TLPWDLWTT''' | ||
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[[Category: Miele, A E.]] | [[Category: Miele, A E.]] | ||
[[Category: Owen, D J.]] | [[Category: Owen, D J.]] | ||
| - | [[Category: | + | [[Category: Clathrin]] |
| - | [[Category: | + | [[Category: Cytoskeleton]] |
| - | [[Category: | + | [[Category: Endocytosis]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:39:40 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:39, 3 May 2008
CLATHRIN TERMINAL DOMAIN COMPLEXED WITH TLPWDLWTT
Overview
During the assembly of clathrin-coated vesicles, many peripheral membrane proteins, including the amphiphysins, use LLDLD-type clathrin-box motifs to interact with the N-terminal beta-propeller domain (TD) of clathrin. The 2.3 A-resolution structure of the clathrin TD in complex with a TLPWDLWTT peptide from amphiphysin 1 delineates a second clathrin-binding motif, PWXXW (the W box), that binds at a site on the TD remote from the clathrin box-binding site. The presence of both sequence motifs within the unstructured region of the amphiphysins allows them to bind more tightly to free TDs than do other endocytic proteins that contain only clathrin-box motifs. This property, along with the propensity of the N-terminal BAR domain to bind curved membranes, will preferentially localize amphiphysin and its partner, dynamin, to the periphery of invaginated clathrin lattices.
About this Structure
1UTC is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.
Reference
Two distinct interaction motifs in amphiphysin bind two independent sites on the clathrin terminal domain beta-propeller., Miele AE, Watson PJ, Evans PR, Traub LM, Owen DJ, Nat Struct Mol Biol. 2004 Mar;11(3):242-8. Epub 2004 Feb 15. PMID:14981508 Page seeded by OCA on Sat May 3 11:39:40 2008
