5vjl
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of H7 hemagglutinin mutant (V186K, K193T, G228S) from the influenza virus A/Shanghai/2/2013 (H7N9) with LSTc== | |
| - | + | <StructureSection load='5vjl' size='340' side='right' caption='[[5vjl]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5vjl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VJL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vjk|5vjk]], [[5vjm|5vjm]]</td></tr> |
| - | [[Category: Wilson, I | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vjl OCA], [http://pdbe.org/5vjl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vjl RCSB], [http://www.ebi.ac.uk/pdbsum/5vjl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vjl ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/R4NN21_9INFA R4NN21_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Wilson, I A]] | ||
[[Category: Zhu, X]] | [[Category: Zhu, X]] | ||
| + | [[Category: Hemagglutinin]] | ||
| + | [[Category: Influenza virus]] | ||
| + | [[Category: Mutant]] | ||
| + | [[Category: Receptor specificity]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 13:52, 24 May 2017
Crystal structure of H7 hemagglutinin mutant (V186K, K193T, G228S) from the influenza virus A/Shanghai/2/2013 (H7N9) with LSTc
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