1uuh

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[[Image:1uuh.jpg|left|200px]]
[[Image:1uuh.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1uuh", creates the "Structure Box" on the page.
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{{STRUCTURE_1uuh| PDB=1uuh | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uuh OCA], [http://www.ebi.ac.uk/pdbsum/1uuh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uuh RCSB]</span>
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'''HYALURONAN BINDING DOMAIN OF HUMAN CD44'''
'''HYALURONAN BINDING DOMAIN OF HUMAN CD44'''
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[[Category: Teriete, P.]]
[[Category: Teriete, P.]]
[[Category: Wright, A.]]
[[Category: Wright, A.]]
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[[Category: c-type lectin]]
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[[Category: C-type lectin]]
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[[Category: extracellular matrix]]
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[[Category: Extracellular matrix]]
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[[Category: hyaluronan]]
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[[Category: Hyaluronan]]
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[[Category: link-domain]]
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[[Category: Link-domain]]
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[[Category: receptor]]
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[[Category: Receptor]]
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[[Category: sugar-binding]]
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[[Category: Sugar-binding]]
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Revision as of 08:42, 3 May 2008

Image:1uuh.jpg

Template:STRUCTURE 1uuh

HYALURONAN BINDING DOMAIN OF HUMAN CD44


Overview

Adhesive interactions involving CD44, the cell surface receptor for hyaluronan, underlie fundamental processes such as inflammatory leukocyte homing and tumor metastasis. Regulation of such events is critical and appears to be effected by changes in CD44 N-glycosylation that switch the receptor "on" or "off" under appropriate circumstances. How altered glycosylation influences binding of hyaluronan to the lectin-like Link module in CD44 is unclear, although evidence suggests additional flanking sequences peculiar to CD44 may be involved. Here we show using X-ray crystallography and NMR spectroscopy that these sequences form a lobular extension to the Link module, creating an enlarged HA binding domain and a formerly unidentified protein fold. Moreover, the disposition of key N-glycosylation sites reveals how specific sugar chains could alter both the affinity and avidity of CD44 HA binding. Our results provide the necessary structural framework for understanding the diverse functions of CD44 and developing novel therapeutic strategies.

About this Structure

1UUH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44., Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, Lowe E, Mahoney DJ, Tammi MI, Kahmann JD, Campbell ID, Day AJ, Jackson DG, Mol Cell. 2004 Feb 27;13(4):483-96. PMID:14992719 Page seeded by OCA on Sat May 3 11:42:34 2008

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