1uun

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[[Image:1uun.jpg|left|200px]]
[[Image:1uun.jpg|left|200px]]
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{{Structure
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|PDB= 1uun |SIZE=350|CAPTION= <scene name='initialview01'>1uun</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1uun", creates the "Structure Box" on the page.
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{{STRUCTURE_1uun| PDB=1uun | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uun OCA], [http://www.ebi.ac.uk/pdbsum/1uun PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uun RCSB]</span>
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'''MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)'''
'''MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)'''
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[[Category: Niederweis, M.]]
[[Category: Niederweis, M.]]
[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
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[[Category: mycobacteria]]
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[[Category: Mycobacteria]]
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[[Category: porin]]
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[[Category: Porin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:43:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:15:32 2008''
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Revision as of 08:43, 3 May 2008

Image:1uun.jpg

Template:STRUCTURE 1uun

MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)


Overview

Mycobacteria have low-permeability outer membranes that render them resistant to most antibiotics. Hydrophilic nutrients can enter by way of transmembrane-channel proteins called porins. An x-ray analysis of the main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric goblet-like conformation with a single central channel. This is the first structure of a mycobacterial outer-membrane protein. No structure-related protein was found in the Protein Data Bank. MspA contains two consecutive beta barrels with nonpolar outer surfaces that form a ribbon around the porin, which is too narrow to fit the thickness of the mycobacterial outer membrane in contemporary models.

About this Structure

1UUN is a Single protein structure of sequence from Mycobacterium smegmatis. Full crystallographic information is available from OCA.

Reference

The structure of a mycobacterial outer-membrane channel., Faller M, Niederweis M, Schulz GE, Science. 2004 Feb 20;303(5661):1189-92. PMID:14976314 Page seeded by OCA on Sat May 3 11:43:03 2008

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