This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1uun
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1uun.jpg|left|200px]] | [[Image:1uun.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1uun", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | | | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | + | --> | |
| - | + | {{STRUCTURE_1uun| PDB=1uun | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)''' | '''MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)''' | ||
| Line 28: | Line 25: | ||
[[Category: Niederweis, M.]] | [[Category: Niederweis, M.]] | ||
[[Category: Schulz, G E.]] | [[Category: Schulz, G E.]] | ||
| - | [[Category: | + | [[Category: Mycobacteria]] |
| - | [[Category: | + | [[Category: Porin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:43:03 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:43, 3 May 2008
MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)
Overview
Mycobacteria have low-permeability outer membranes that render them resistant to most antibiotics. Hydrophilic nutrients can enter by way of transmembrane-channel proteins called porins. An x-ray analysis of the main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric goblet-like conformation with a single central channel. This is the first structure of a mycobacterial outer-membrane protein. No structure-related protein was found in the Protein Data Bank. MspA contains two consecutive beta barrels with nonpolar outer surfaces that form a ribbon around the porin, which is too narrow to fit the thickness of the mycobacterial outer membrane in contemporary models.
About this Structure
1UUN is a Single protein structure of sequence from Mycobacterium smegmatis. Full crystallographic information is available from OCA.
Reference
The structure of a mycobacterial outer-membrane channel., Faller M, Niederweis M, Schulz GE, Science. 2004 Feb 20;303(5661):1189-92. PMID:14976314 Page seeded by OCA on Sat May 3 11:43:03 2008
