1uw1

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[[Image:1uw1.jpg|left|200px]]
[[Image:1uw1.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1uw1 |SIZE=350|CAPTION= <scene name='initialview01'>1uw1</scene>, resolution 1.94&Aring;
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The line below this paragraph, containing "STRUCTURE_1uw1", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1uw1| PDB=1uw1 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw1 OCA], [http://www.ebi.ac.uk/pdbsum/1uw1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uw1 RCSB]</span>
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}}
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'''A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION'''
'''A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION'''
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==About this Structure==
==About this Structure==
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1UW1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW1 OCA].
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1UW1 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW1 OCA].
==Reference==
==Reference==
A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15024384 15024384]
A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15024384 15024384]
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[[Category: ]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Sollazzo, M.]]
[[Category: Sollazzo, M.]]
[[Category: Surdo, P Lo.]]
[[Category: Surdo, P Lo.]]
[[Category: Walsh, M A.]]
[[Category: Walsh, M A.]]
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[[Category: in vitro evolution]]
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[[Category: In vitro evolution]]
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[[Category: nucleotide binding protein]]
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[[Category: Nucleotide binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:45:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:16:03 2008''
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Revision as of 08:45, 3 May 2008

Image:1uw1.jpg

Template:STRUCTURE 1uw1

A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION


Overview

A great challenge to biologists is to create proteins with novel folds and tailored functions. As an alternative to de novo protein design, we investigated the structure of a randomly generated protein targeted to bind ATP. The crystal structure reveals a novel alpha/beta fold bound to its ligand, representing both the first protein structure derived from in vitro evolution and the first nucleotide-binding protein stabilized by a zinc ion.

About this Structure

1UW1 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:15024384 Page seeded by OCA on Sat May 3 11:45:38 2008

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