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1uw1
From Proteopedia
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[[Image:1uw1.jpg|left|200px]] | [[Image:1uw1.jpg|left|200px]] | ||
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| - | + | {{STRUCTURE_1uw1| PDB=1uw1 | SCENE= }} | |
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'''A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION''' | '''A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1UW1 is a [[Single protein]] structure | + | 1UW1 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW1 OCA]. |
==Reference== | ==Reference== | ||
A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15024384 15024384] | A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15024384 15024384] | ||
| - | [[Category: ]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Sollazzo, M.]] | [[Category: Sollazzo, M.]] | ||
[[Category: Surdo, P Lo.]] | [[Category: Surdo, P Lo.]] | ||
[[Category: Walsh, M A.]] | [[Category: Walsh, M A.]] | ||
| - | [[Category: | + | [[Category: In vitro evolution]] |
| - | [[Category: | + | [[Category: Nucleotide binding protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:45:38 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:45, 3 May 2008
A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION
Overview
A great challenge to biologists is to create proteins with novel folds and tailored functions. As an alternative to de novo protein design, we investigated the structure of a randomly generated protein targeted to bind ATP. The crystal structure reveals a novel alpha/beta fold bound to its ligand, representing both the first protein structure derived from in vitro evolution and the first nucleotide-binding protein stabilized by a zinc ion.
About this Structure
1UW1 is a Single protein structure. Full crystallographic information is available from OCA.
Reference
A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:15024384 Page seeded by OCA on Sat May 3 11:45:38 2008
