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Sandbox GGC3
From Proteopedia
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Tuberculosis is an infectious disease that is the second leading cause of death worldwide. Mycobacterium tuberculosis is an intracellular bacterial pathogen in infected macrophages. It contributes to antibiotic resistance and plays a critical role in regulating host response and aid survival of pathogen. LprG determines the distribution components of mycobacterium tuberculosis cell envelope. <ref name="rasmol" /> | Tuberculosis is an infectious disease that is the second leading cause of death worldwide. Mycobacterium tuberculosis is an intracellular bacterial pathogen in infected macrophages. It contributes to antibiotic resistance and plays a critical role in regulating host response and aid survival of pathogen. LprG determines the distribution components of mycobacterium tuberculosis cell envelope. <ref name="rasmol" /> | ||
| - | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
| - | LprG (4ZRA) consists of two chains A and C containing alpha-beta folds. <scene name='75/752266/Sheets_and_helices/1'>Chain A </scene> contains 10 anti-parallel ß-sheets by 6 α-helices which defines the central cavity entrance. The | + | LprG (4ZRA) consists of two chains A and C containing alpha-beta folds. <scene name='75/752266/Sheets_and_helices/1'>Chain A </scene> contains 10 anti-parallel ß-sheets by 6 α-helices which defines the central cavity entrance. The <scene name='75/752266/Sheets_and_helices/2'>glyceryl group</scene> is located at the entrance and has a conserved orientation.There are three acyl chains bound within the cavity sn1, sn2, and <scene name='75/752266/Ligand_selected/6'> sn3</scene> which form interactions with hydrophobic residue side chains within the cavity. The third acyl chain is exposed to the solvent and the other two (sn1 and sn2) are not shown. At the cavity entrance the hydophilic glyceryl interacts with <scene name='75/752266/Sn3-chain/3'> Ser72 </scene>. The sn3 chain is near two <scene name='75/752266/Phe_leu_ile/3'>hydrophobic</scene> grooves that contain Ile, Leu, Val, and Phe. These grooves could facilitate the binding of TAG with other longer acyl chains.<ref name="rasmol" /> |
Revision as of 01:27, 1 May 2017
Mycobacterial Lipoprotein
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References
- ↑ 1.0 1.1 1.2 1.3 Martinot AJ, Farrow M, Bai L, Layre E, Cheng TY, Tsai JH, Iqbal J, Annand JW, Sullivan ZA, Hussain MM, Sacchettini J, Moody DB, Seeliger JC, Rubin EJ. Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis. PLoS Pathog. 2016 Jan 11;12(1):e1005351. doi: 10.1371/journal.ppat.1005351., eCollection 2016 Jan. PMID:26751071 doi:http://dx.doi.org/10.1371/journal.ppat.1005351
