5vk1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human MDM4 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI== | |
| - | + | <StructureSection load='5vk1' size='340' side='right' caption='[[5vk1]], [[Resolution|resolution]] 2.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5vk1]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VK1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VK1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=9E7:'>9E7</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3eqy|3eqy]], [[5vk0|5vk0]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vk1 OCA], [http://pdbe.org/5vk1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vk1 RCSB], [http://www.ebi.ac.uk/pdbsum/5vk1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vk1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gohain, N]] | ||
[[Category: Pazgier, M]] | [[Category: Pazgier, M]] | ||
| - | [[Category: Tolbert, W | + | [[Category: Tolbert, W D]] |
| - | [[Category: | + | [[Category: Mdmx]] |
| + | [[Category: Mdmx-peptide inhibitor complex]] | ||
| + | [[Category: Metal-binding]] | ||
| + | [[Category: Nucleus]] | ||
| + | [[Category: Oncoprotein]] | ||
| + | [[Category: Signaling protein-inhibitor complex]] | ||
| + | [[Category: Stapled peptide]] | ||
| + | [[Category: Zinc-finger]] | ||
Revision as of 05:24, 25 April 2018
Crystal structure of human MDM4 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI
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