1uzi
From Proteopedia
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'''C3 EXOENZYME FROM CLOSTRIDIUM BOTULINUM, TETRAGONAL FORM''' | '''C3 EXOENZYME FROM CLOSTRIDIUM BOTULINUM, TETRAGONAL FORM''' | ||
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C3 exoenzyme from Clostridium botulinum: structure of a tetragonal crystal form and a reassessment of NAD-induced flexure., Evans HR, Holloway DE, Sutton JM, Ayriss J, Shone CC, Acharya KR, Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1502-5. Epub 2004, Jul 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15272191 15272191] | C3 exoenzyme from Clostridium botulinum: structure of a tetragonal crystal form and a reassessment of NAD-induced flexure., Evans HR, Holloway DE, Sutton JM, Ayriss J, Shone CC, Acharya KR, Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1502-5. Epub 2004, Jul 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15272191 15272191] | ||
[[Category: Clostridium botulinum]] | [[Category: Clostridium botulinum]] | ||
| - | [[Category: NAD(+) ADP-ribosyltransferase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Acharya, K R.]] | [[Category: Acharya, K R.]] | ||
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[[Category: Shone, C C.]] | [[Category: Shone, C C.]] | ||
[[Category: Sutton, J M.]] | [[Category: Sutton, J M.]] | ||
| - | [[Category: | + | [[Category: Adp-ribosyltransferase]] |
| - | [[Category: | + | [[Category: C3]] |
| - | [[Category: | + | [[Category: Transferase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:54:21 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:54, 3 May 2008
C3 EXOENZYME FROM CLOSTRIDIUM BOTULINUM, TETRAGONAL FORM
Overview
C3 exoenzyme from Clostridium botulinum (C3bot1) ADP-ribosylates and thereby inactivates Rho A, B and C GTPases in mammalian cells. The structure of a tetragonal crystal form has been determined by molecular replacement and refined to 1.89 A resolution. It is very similar to the apo structures determined previously from two different monoclinic crystal forms. An objective reassessment of available apo and nucleotide-bound C3bot1 structures indicates that, contrary to a previous report, the protein possesses a rigid core formed largely of beta-strands and that the general flexure that accompanies NAD binding is concentrated in two peripheral lobes. Tetragonal crystals disintegrate in the presence of NAD, most likely because of disruption of essential crystal contacts.
About this Structure
1UZI is a Single protein structure of sequence from Clostridium botulinum. Full crystallographic information is available from OCA.
Reference
C3 exoenzyme from Clostridium botulinum: structure of a tetragonal crystal form and a reassessment of NAD-induced flexure., Evans HR, Holloway DE, Sutton JM, Ayriss J, Shone CC, Acharya KR, Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1502-5. Epub 2004, Jul 21. PMID:15272191 Page seeded by OCA on Sat May 3 11:54:21 2008
