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Ets1

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<StructureSection load='1mdm' size='340' side='right' caption='Structure of mouse Ets1 ETS domain (green) complex with paired box protein Pax5 (magenta) and MB-1 promoter DNA (PDB code [[1mdm]]).' scene='59/595751/Cv/1'>
<StructureSection load='1mdm' size='340' side='right' caption='Structure of mouse Ets1 ETS domain (green) complex with paired box protein Pax5 (magenta) and MB-1 promoter DNA (PDB code [[1mdm]]).' scene='59/595751/Cv/1'>
== Function ==
== Function ==
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'''Ets1 (E26 Transformation-Specific)''' is a proto-oncogene translation factor. Ets1 contributes to the regulation of cellular differentiation<ref>PMID:17986575</ref> .
+
'''Ets1 (E26 Transformation-Specific)''' or '''p54''' is a proto-oncogene translation factor. Ets1 contributes to the regulation of cellular differentiation<ref>PMID:17986575</ref> .
== Relevance ==
== Relevance ==
Ets1 promotes invasive behavior in endothelial cells, smooth muscle cells and epithelial cancer cells.
Ets1 promotes invasive behavior in endothelial cells, smooth muscle cells and epithelial cancer cells.

Revision as of 07:14, 20 July 2021

Structure of mouse Ets1 ETS domain (green) complex with paired box protein Pax5 (magenta) and MB-1 promoter DNA (PDB code 1mdm).

Drag the structure with the mouse to rotate

3D Structures of Ets1

Updated on 20-July-2021

References

  1. ↑ Dwyer J, Li H, Xu D, Liu JP. Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family. Ann N Y Acad Sci. 2007 Oct;1114:36-47. PMID:17986575 doi:http://dx.doi.org/10.1196/annals.1396.022
  2. ↑ Garvie CW, Pufall MA, Graves BJ, Wolberger C. Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships. J Biol Chem. 2002 Nov 22;277(47):45529-36. Epub 2002 Sep 6. PMID:12221090 doi:10.1074/jbc.M206327200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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