1v3p

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[[Image:1v3p.gif|left|200px]]
[[Image:1v3p.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1v3p |SIZE=350|CAPTION= <scene name='initialview01'>1v3p</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1v3p", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=I5C:5-IODO-2&#39;-DEOXY-CYTIDINE-5&#39;-MONOPHOSPHATE'>I5C</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1v3p| PDB=1v3p | SCENE= }}
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|RELATEDENTRY=[[1v3n|1V3N]], [[1v3o|1V3O]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v3p OCA], [http://www.ebi.ac.uk/pdbsum/1v3p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1v3p RCSB]</span>
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}}
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'''Crystal structure of d(GCGAGAGC): the DNA octaplex structure with I-motif of G-quartet'''
'''Crystal structure of d(GCGAGAGC): the DNA octaplex structure with I-motif of G-quartet'''
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==About this Structure==
==About this Structure==
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1V3P is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V3P OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V3P OCA].
==Reference==
==Reference==
Crystal structures of a DNA octaplex with I-motif of G-quartets and its splitting into two quadruplexes suggest a folding mechanism of eight tandem repeats., Kondo J, Adachi W, Umeda S, Sunami T, Takenaka A, Nucleic Acids Res. 2004 May 7;32(8):2541-9. Print 2004. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15133122 15133122]
Crystal structures of a DNA octaplex with I-motif of G-quartets and its splitting into two quadruplexes suggest a folding mechanism of eight tandem repeats., Kondo J, Adachi W, Umeda S, Sunami T, Takenaka A, Nucleic Acids Res. 2004 May 7;32(8):2541-9. Print 2004. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15133122 15133122]
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[[Category: Protein complex]]
 
[[Category: Kondo, J.]]
[[Category: Kondo, J.]]
[[Category: Sunami, T.]]
[[Category: Sunami, T.]]
[[Category: Takenaka, A.]]
[[Category: Takenaka, A.]]
[[Category: Umeda, S.]]
[[Category: Umeda, S.]]
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[[Category: base-intercalated duplex]]
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[[Category: Base-intercalated duplex]]
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[[Category: base-intercalated motif]]
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[[Category: Base-intercalated motif]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: deoxyribonucleic acid]]
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[[Category: Deoxyribonucleic acid]]
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[[Category: dna]]
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[[Category: Dna]]
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[[Category: g-quartet]]
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[[Category: G-quartet]]
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[[Category: i-motif]]
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[[Category: I-motif]]
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[[Category: i-motif of g-quartet]]
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[[Category: I-motif of g-quartet]]
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[[Category: octaplex]]
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[[Category: Octaplex]]
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[[Category: quadruplex]]
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[[Category: Quadruplex]]
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[[Category: sheared g:a pair]]
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[[Category: Sheared g:a pair]]
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[[Category: x-ray analysis]]
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[[Category: X-ray analysis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:02:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:19:02 2008''
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Revision as of 09:02, 3 May 2008

Image:1v3p.gif

Template:STRUCTURE 1v3p

Crystal structure of d(GCGAGAGC): the DNA octaplex structure with I-motif of G-quartet


Overview

Recent genomic analyses revealed many kinds of tandem repeats of specific sequences. Some of them are related to genetic diseases, but their biological functions and structures are still unknown. Two X-ray structures of a short DNA fragment d(gcGA[G]1Agc) show that four base-intercalated duplexes are assembled to form an octaplex at a low K+ concentration, in which the eight G5 residues form a stacked double G-quartet in the central part. At a higher K+ concentration, however, the octaplex is split into just two halves. These structural features suggest a folding process of eight tandem repeats of d(ccGA[G]4Agg), according to a double Greek-key motif. Such a packaging of the repeats could facilitate slippage of a certain sequence during DNA replication, to induce increase or decrease of the repeats.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structures of a DNA octaplex with I-motif of G-quartets and its splitting into two quadruplexes suggest a folding mechanism of eight tandem repeats., Kondo J, Adachi W, Umeda S, Sunami T, Takenaka A, Nucleic Acids Res. 2004 May 7;32(8):2541-9. Print 2004. PMID:15133122 Page seeded by OCA on Sat May 3 12:02:14 2008

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