1v7f

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[[Image:1v7f.jpg|left|200px]]
[[Image:1v7f.jpg|left|200px]]
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{{Structure
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|PDB= 1v7f |SIZE=350|CAPTION= <scene name='initialview01'>1v7f</scene>
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The line below this paragraph, containing "STRUCTURE_1v7f", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_1v7f| PDB=1v7f | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v7f OCA], [http://www.ebi.ac.uk/pdbsum/1v7f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1v7f RCSB]</span>
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'''solution structure of phrixotoxin 1'''
'''solution structure of phrixotoxin 1'''
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==About this Structure==
==About this Structure==
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1V7F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V7F OCA].
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1V7F is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V7F OCA].
==Reference==
==Reference==
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[[Category: Lazdunski, M.]]
[[Category: Lazdunski, M.]]
[[Category: Villegas, E.]]
[[Category: Villegas, E.]]
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[[Category: toxin]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:10:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:20:31 2008''
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Revision as of 09:10, 3 May 2008

Image:1v7f.jpg

Template:STRUCTURE 1v7f

solution structure of phrixotoxin 1


Overview

Animal toxins block voltage-dependent potassium channels (Kv) either by occluding the conduction pore (pore blockers) or by modifying the channel gating properties (gating modifiers). Gating modifiers of Kv channels bind to four equivalent extracellular sites near the S3 and S4 segments, close to the voltage sensor. Phrixotoxins are gating modifiers that bind preferentially to the closed state of the channel and fold into the Inhibitory Cystine Knot structural motif. We have solved the solution structure of Phrixotoxin 1, a gating modifier of Kv4 potassium channels. Analysis of the molecular surface and the electrostatic anisotropy of Phrixotoxin 1 and of other toxins acting on voltage-dependent potassium channels allowed us to propose a toxin interacting surface that encompasses both the surface from which the dipole moment emerges and a neighboring hydrophobic surface rich in aromatic residues.

About this Structure

1V7F is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus., Chagot B, Escoubas P, Villegas E, Bernard C, Ferrat G, Corzo G, Lazdunski M, Darbon H, Protein Sci. 2004 May;13(5):1197-208. PMID:15096626 Page seeded by OCA on Sat May 3 12:10:44 2008

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