Fibroblast growth factor receptor
From Proteopedia
(Difference between revisions)
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*FGFR1 | *FGFR1 | ||
| - | *''FGFR1 tyrosine kinase domain'' | + | *''FGFR1 tyrosine kinase domain residues 458-765'' |
**[[1fgk]], [[3kxx]], [[3ky2]], [[4rwi]], [[5flf]] – hFGFR1 TKD (mutant) - human <br /> | **[[1fgk]], [[3kxx]], [[3ky2]], [[4rwi]], [[5flf]] – hFGFR1 TKD (mutant) - human <br /> | ||
**[[4uwy]] – hFGFR1 TKD <br /> | **[[4uwy]] – hFGFR1 TKD <br /> | ||
| - | **[[4wun]], [[5am6]], [[5ew8]] – hFGFR1 TKD + inhibitor <br /> | + | **[[4wun]], [[5am6]], [[5ew8]], [[5o49]], [[5ora]] – hFGFR1 TKD + inhibitor <br /> |
| - | **[[1agw]], [[1fgi]], [[2fgi]], [[3c4f]], [[3js2]], [[3rhx]], [[4f63]], [[4f64]], [[4f65]], [[3tt0]], [[4nk9]], [[4nka]], [[4nks]], [[5b7v]], [[5am7]], [[4rwj]], [[4rwk]], [[4rwl]], [[4uwb]], [[4uwc]], [[4zsa]], [[5uq0]] – hFGFR1 TKD (mutant) + inhibitor <br /> | + | **[[1agw]], [[1fgi]], [[2fgi]], [[3c4f]], [[3js2]], [[3rhx]], [[4f63]], [[4f64]], [[4f65]], [[3tt0]], [[4nk9]], [[4nka]], [[4nks]], [[5b7v]], [[5am7]], [[4rwj]], [[4rwk]], [[4rwl]], [[4uwb]], [[4uwc]], [[4zsa]], [[5uq0]], [[5vnd]], [[5ur1]] – hFGFR1 TKD (mutant) + inhibitor <br /> |
**[[3krj]] – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor <br /> | **[[3krj]] – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor <br /> | ||
**[[1xr0]] – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR<br /> | **[[1xr0]] – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR<br /> | ||
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**[[3gql]] – hFGFR1 TKD (mutant) + substrate <br /> | **[[3gql]] – hFGFR1 TKD (mutant) + substrate <br /> | ||
| - | *''FGFR1 ligand-binding domain'' | + | *''FGFR1 ligand-binding domain D1 residues 35-208'' |
**[[2cr3]] – hFGFR1 LBD D1 - NMR<br /> | **[[2cr3]] – hFGFR1 LBD D1 - NMR<br /> | ||
**[[2ckn]] – FGFR1 LBD D1 – mouse - NMR<br /> | **[[2ckn]] – FGFR1 LBD D1 – mouse - NMR<br /> | ||
| - | *''FGFR1 complex with FGF'' | + | *''FGFR1 D1 complex with FGF'' |
| + | |||
| + | **[[5w59]] – hFGFR1 LBD D1 + FGF9<br /> | ||
| + | |||
| + | *''FGFR1 D2,D3 residues 142-365 complex with FGF'' | ||
**[[3ojv]] – hFGFR1 LBD D2,D3 (mutant) + hFGF1 - human <br /> | **[[3ojv]] – hFGFR1 LBD D2,D3 (mutant) + hFGF1 - human <br /> | ||
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**[[1evt]] – hFGFR1 LBD D2,D3 + hFGF1 <br /> | **[[1evt]] – hFGFR1 LBD D2,D3 + hFGF1 <br /> | ||
**[[1fq9]] – hFGFR1 (mutant) LBD D2,D3 + hFGF2 (mutant) + HS<br /> | **[[1fq9]] – hFGFR1 (mutant) LBD D2,D3 + hFGF2 (mutant) + HS<br /> | ||
| + | **[[5w21]] – hFGFR1 LBD D2,D3 + hFGF23 + klotho <br /> | ||
*FGFR2 | *FGFR2 | ||
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**[[4tye]], [[4tyg]], [[4tyi]], [[4tyj]] – hFGFR4 TKD <br /> | **[[4tye]], [[4tyg]], [[4tyi]], [[4tyj]] – hFGFR4 TKD <br /> | ||
**[[4qqj]], [[4qqt]] – hFGFR4 TKD (mutant) <br /> | **[[4qqj]], [[4qqt]] – hFGFR4 TKD (mutant) <br /> | ||
| - | **[[5jkg]] – hFGFR4 TKD + inhibitor<br /> | + | **[[5jkg]], [[5nwz]], [[5nud]] – hFGFR4 TKD + inhibitor<br /> |
**[[4qrc]], [[4r6v]], [[4qqc]], [[4qq5]], [[4uxq]], [[4xcu]] – hFGFR4 TKD (mutant) + irreversible inhibitor<br /> | **[[4qrc]], [[4r6v]], [[4qqc]], [[4qq5]], [[4uxq]], [[4xcu]] – hFGFR4 TKD (mutant) + irreversible inhibitor<br /> | ||
Revision as of 10:04, 24 May 2018
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3D structures of fibroblast growth factor receptor
Updated on 24-May-2018
References
- ↑ Coutts JC, Gallagher JT. Receptors for fibroblast growth factors. Immunol Cell Biol. 1995 Dec;73(6):584-9. PMID:8713482 doi:http://dx.doi.org/10.1038/icb.1995.92
- ↑ Wilkin DJ, Szabo JK, Cameron R, Henderson S, Bellus GA, Mack ML, Kaitila I, Loughlin J, Munnich A, Sykes B, Bonaventure J, Francomano CA. Mutations in fibroblast growth-factor receptor 3 in sporadic cases of achondroplasia occur exclusively on the paternally derived chromosome. Am J Hum Genet. 1998 Sep;63(3):711-6. PMID:9718331 doi:http://dx.doi.org/10.1086/302000
- ↑ Intini D, Baldini L, Fabris S, Lombardi L, Ciceri G, Maiolo AT, Neri A. Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14). Br J Haematol. 2001 Aug;114(2):362-4. PMID:11529856
- ↑ Meyers GA, Orlow SJ, Munro IR, Przylepa KA, Jabs EW. Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. Nat Genet. 1995 Dec;11(4):462-4. PMID:7493034 doi:http://dx.doi.org/10.1038/ng1295-462
