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Filamin

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Line 28: Line 28:
**[[2k7q]] - hFLNA domains 18-19<br />
**[[2k7q]] - hFLNA domains 18-19<br />
**[[2j3s]] - hFLNA domains 19-21<br />
**[[2j3s]] - hFLNA domains 19-21<br />
-
**[[2w0p]] - hFLNA domain 21+migfilin peptide<br />
+
**[[2w0p]], [[2mtp]] - hFLNA domain 21+migfilin peptide<br />
**[[2jf1]], [[2brq]] - hFLNA domain 21+integrin peptide<br />
**[[2jf1]], [[2brq]] - hFLNA domain 21+integrin peptide<br />
**[[2k3t]] - hFLNA domain 23 – NMR<br />
**[[2k3t]] - hFLNA domain 23 – NMR<br />

Revision as of 07:09, 27 May 2018

Human Filamin B actin-binding domain complex with sulfate and carbonate (PDB code 2wa5)

Drag the structure with the mouse to rotate

3D structures of filamin

Updated on 27-May-2018

References

  1. ↑ Clark AR, Sawyer GM, Robertson SP, Sutherland-Smith AJ. Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders. Hum Mol Genet. 2009 Dec 15;18(24):4791-800. Epub 2009 Sep 22. PMID:19773341 doi:10.1093/hmg/ddp442
  2. ↑ Sawyer GM, Clark AR, Robertson SP, Sutherland-Smith AJ. Disease-associated substitutions in the filamin B actin binding domain confer enhanced actin binding affinity in the absence of major structural disturbance: Insights from the crystal structures of filamin B actin binding domains. J Mol Biol. 2009 Jul 31;390(5):1030-47. Epub 2009 Jun 6. PMID:19505475 doi:10.1016/j.jmb.2009.06.009
  3. ↑ van der Flier A, Sonnenberg A. Structural and functional aspects of filamins. Biochim Biophys Acta. 2001 Apr 23;1538(2-3):99-117. PMID:11336782
  4. ↑ Brunetti-Pierri N, Torrado M, Fernandez Mdel C, Tello AM, Arberas CL, Cardinale A, Piccolo P, Bacino CA. Terminal osseous dysplasia with pigmentary defects (TODPD) due to a recurrent filamin A (FLNA) mutation. Mol Genet Genomic Med. 2014 Nov;2(6):467-71. doi: 10.1002/mgg3.90. Epub 2014 Aug , 8. PMID:25614868 doi:http://dx.doi.org/10.1002/mgg3.90

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Michal Harel, Alexander Berchansky, Jaime Prilusky

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