5q1c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5q1c" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5q1c is ON HOLD
+
==Ligand binding to FARNESOID-X-RECEPTOR==
-
 
+
<StructureSection load='5q1c' size='340' side='right' caption='[[5q1c]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
Authors: Benz, J., Burger, D., Joseph, C., Rudolph, M.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5q1c]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Q1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Q1C FirstGlance]. <br>
-
Description: Ligand binding to FARNESOID-X-RECEPTOR
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9NA:(2S)-2-cyclohexyl-2-[2-(2,6-dimethoxypyridin-3-yl)-5,6-difluoro-1H-benzimidazol-1-yl]-N-(trans-4-hydroxycyclohexyl)acetamide'>9NA</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5q1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5q1c OCA], [http://pdbe.org/5q1c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5q1c RCSB], [http://www.ebi.ac.uk/pdbsum/5q1c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5q1c ProSAT]</span></td></tr>
-
[[Category: Joseph, C]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Benz, J]]
[[Category: Benz, J]]
-
[[Category: Rudolph, M]]
 
[[Category: Burger, D]]
[[Category: Burger, D]]
 +
[[Category: Burley, S K]]
 +
[[Category: Joseph, C]]
 +
[[Category: Kuhn, B]]
 +
[[Category: Rudolph, M G]]
 +
[[Category: Ruf, A]]
 +
[[Category: Shao, C]]
 +
[[Category: Thoma, R]]
 +
[[Category: Yang, H]]
 +
[[Category: D3r]]
 +
[[Category: Docking]]
 +
[[Category: Fxr]]
 +
[[Category: Transcription]]

Revision as of 16:55, 20 October 2017

Ligand binding to FARNESOID-X-RECEPTOR

5q1c, resolution 2.30Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5q1c"
Personal tools