5q1h

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m (Protected "5q1h" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5q1h is ON HOLD
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==Ligand binding to FARNESOID-X-RECEPTOR==
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<StructureSection load='5q1h' size='340' side='right' caption='[[5q1h]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors: Benz, J., Burger, D., Joseph, C., Rudolph, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5q1h]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Q1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Q1H FirstGlance]. <br>
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Description: Ligand binding to FARNESOID-X-RECEPTOR
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9NP:(2S)-N,2-dicyclohexyl-2-{2-[4-(1H-tetrazol-5-yl)phenyl]-1H-benzimidazol-1-yl}acetamide'>9NP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5q1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5q1h OCA], [http://pdbe.org/5q1h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5q1h RCSB], [http://www.ebi.ac.uk/pdbsum/5q1h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5q1h ProSAT]</span></td></tr>
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[[Category: Joseph, C]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Benz, J]]
[[Category: Benz, J]]
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[[Category: Rudolph, M]]
 
[[Category: Burger, D]]
[[Category: Burger, D]]
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[[Category: Burley, S K]]
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[[Category: Joseph, C]]
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[[Category: Kuhn, B]]
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[[Category: Rudolph, M G]]
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[[Category: Ruf, A]]
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[[Category: Shao, C]]
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[[Category: Thoma, R]]
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[[Category: Yang, H]]
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[[Category: D3r]]
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[[Category: Docking]]
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[[Category: Fxr]]
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[[Category: Transcription]]

Revision as of 16:56, 20 October 2017

Ligand binding to FARNESOID-X-RECEPTOR

5q1h, resolution 2.20Å

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