1vfi

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vfi OCA], [http://www.ebi.ac.uk/pdbsum/1vfi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vfi RCSB]</span>
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'''Solution Structure of Vanabin2 (RUH-017), a Vanadium-binding Protein from Ascidia sydneiensis samea'''
'''Solution Structure of Vanabin2 (RUH-017), a Vanadium-binding Protein from Ascidia sydneiensis samea'''
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[[Category: Yokoyama, S.]]
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[[Category: Ascidian]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: Rsgi]]
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[[Category: Vanadium-binding]]
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Revision as of 09:28, 3 May 2008

Image:1vfi.gif

Template:STRUCTURE 1vfi

Solution Structure of Vanabin2 (RUH-017), a Vanadium-binding Protein from Ascidia sydneiensis samea


Overview

Ascidians belonging to the suborder Phlebobranchia are known to accumulate high levels of a transition metal, vanadium, in their blood cells, called vanadocytes, although the mechanism for this biological phenomenon remains unclear. Recently, we identified vanadium(IV)-binding proteins, designated as Vanabins, from vanadium-accumulating ascidians. Here, we report the first 3D structure of Vanabin2 from an ascidian, Ascidia sydneiensis samea, in an aqueous solution. The structure revealed a novel bow-shaped conformation, with four alpha-helices connected by nine disulfide bonds. There are no structural homologues reported so far. The 15N heteronuclear single-quantum coherence (HSQC) perturbation experiments of Vanabin2 indicated that vanadyl cations, which are exclusively localized on the same face of the molecule, are coordinated by amine nitrogens derived from amino acid residues such as lysines, arginines, and histidines, as suggested by the electron paramagnetic resonance (EPR) results. The present NMR studies provide information that will contribute toward elucidating the mechanism of vanadium accumulation in ascidians.

About this Structure

1VFI is a Single protein structure of sequence from Ascidia sydneiensis samea. Full crystallographic information is available from OCA.

Reference

Solution structure of Vanabin2, a vanadium(IV)-binding protein from the vanadium-rich ascidian Ascidia sydneiensis samea., Hamada T, Asanuma M, Ueki T, Hayashi F, Kobayashi N, Yokoyama S, Michibata H, Hirota H, J Am Chem Soc. 2005 Mar 30;127(12):4216-22. PMID:15783203 Page seeded by OCA on Sat May 3 12:28:56 2008

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