5vkg
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution-state NMR structural ensemble of human Tsg101 UEV in complex with tenatoprazole== | |
| - | + | <StructureSection load='5vkg' size='340' side='right' caption='[[5vkg]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5vkg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VKG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4N1:4-methoxy-1-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)-3,5-dimethyl-2-(sulfanylmethyl)pyridin-1-ium'>4N1</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vkg OCA], [http://pdbe.org/5vkg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vkg RCSB], [http://www.ebi.ac.uk/pdbsum/5vkg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vkg ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN]] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.<ref>PMID:11916981</ref> <ref>PMID:17853893</ref> <ref>PMID:17556548</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Carter, C]] | ||
| + | [[Category: Ehrlich, L S]] | ||
| + | [[Category: Khan, M]] | ||
| + | [[Category: Leis, J]] | ||
| + | [[Category: Luan, C H]] | ||
| + | [[Category: Powell, M D]] | ||
| + | [[Category: Strickland, M]] | ||
| + | [[Category: Strub, M P]] | ||
| + | [[Category: Tjandra, N]] | ||
| + | [[Category: Watanabe, S]] | ||
| + | [[Category: Cell cycle]] | ||
| + | [[Category: Cell cycle-inhibitor complex]] | ||
| + | [[Category: Escrt-i]] | ||
| + | [[Category: Inhibitor]] | ||
Revision as of 07:32, 15 November 2017
Solution-state NMR structural ensemble of human Tsg101 UEV in complex with tenatoprazole
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Categories: Carter, C | Ehrlich, L S | Khan, M | Leis, J | Luan, C H | Powell, M D | Strickland, M | Strub, M P | Tjandra, N | Watanabe, S | Cell cycle | Cell cycle-inhibitor complex | Escrt-i | Inhibitor
