5vot

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'''Unreleased structure'''
 
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The entry 5vot is ON HOLD until Paper Publication
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==Structure of a Protein Complex==
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<StructureSection load='5vot' size='340' side='right' caption='[[5vot]], [[Resolution|resolution]] 4.90&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5vot]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VOT FirstGlance]. <br>
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Description:
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vou|5vou]], [[5vov|5vov]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vot OCA], [http://pdbe.org/5vot PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vot RCSB], [http://www.ebi.ac.uk/pdbsum/5vot PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vot ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref> [[http://www.uniprot.org/uniprot/CCG2_RAT CCG2_RAT]] Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.<ref>PMID:17880894</ref> <ref>PMID:18817736</ref> <ref>PMID:19234459</ref> <ref>PMID:19265014</ref> <ref>PMID:20805473</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chen, S]]
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[[Category: Gouaux, E]]
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[[Category: Shekhar, M]]
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[[Category: Tajkhorshid, E]]
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[[Category: Wang, Y S]]
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[[Category: Zhao, Y]]
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[[Category: Ampa receptor-tarp complex]]
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[[Category: Membrane protein]]
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[[Category: Metal transport]]
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[[Category: Partially open channel gate]]
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[[Category: Tarp modulation mechanism]]

Revision as of 10:12, 10 September 2017

Structure of a Protein Complex

5vot, resolution 4.90Å

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