1vhr

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[[Image:1vhr.gif|left|200px]]
[[Image:1vhr.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1vhr |SIZE=350|CAPTION= <scene name='initialview01'>1vhr</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1vhr", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=GAA:The+Loop+Containing+The+Putative+General+Acid+ASP+92'>GAA</scene>, <scene name='pdbsite=GAB:The+Loop+Containing+The+Putative+General+Acid+ASP+92'>GAB</scene>, <scene name='pdbsite=PLA:Phosphate+Binding+Loop+Including+Catalytic+Nucleophile+C+...'>PLA</scene>, <scene name='pdbsite=PLB:Phosphate+Binding+Loop+Including+Catalytic+Nucleophile+C+...'>PLB</scene>, <scene name='pdbsite=RCA:Designated+Recognition+Region+In+Primary+Reference.+Prop+...'>RCA</scene>, <scene name='pdbsite=RCB:Designated+Recognition+Region+In+Primary+Reference.+Prop+...'>RCB</scene>, <scene name='pdbsite=VRA:The+Region+Containing+High+Variation+Among+The+Dual-Spec+...'>VRA</scene> and <scene name='pdbsite=VRB:The+Region+Containing+High+Variation+Among+The+Dual-Spec+...'>VRB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1vhr| PDB=1vhr | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vhr OCA], [http://www.ebi.ac.uk/pdbsum/1vhr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vhr RCSB]</span>
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}}
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'''HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE'''
'''HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE'''
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[[Category: Saper, M A.]]
[[Category: Saper, M A.]]
[[Category: Yuvaniyama, J.]]
[[Category: Yuvaniyama, J.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: protein dual-specificity phosphatase]]
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[[Category: Protein dual-specificity phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:33:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:24:37 2008''
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Revision as of 09:33, 3 May 2008

Image:1vhr.gif

Template:STRUCTURE 1vhr

HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE


Overview

Dual specificity protein phosphatases (DSPs) regulate mitogenic signal transduction and control the cell cycle. Here, the crystal structure of a human DSP, vaccinia H1-related phosphatase (or VHR), was determined at 2.1 angstrom resolution. A shallow active site pocket in VHR allows for the hydrolysis of phosphorylated serine, threonine, or tyrosine protein residues, whereas the deeper active site of protein tyrosine phosphatases (PTPs) restricts substrate specificity to only phosphotyrosine. Positively charged crevices near the active site may explain the enzyme's preference for substrates with two phosphorylated residues. The VHR structure defines a conserved structural scaffold for both DSPs and PTPs. A "recognition region," connecting helix alpha1 to strand beta1, may determine differences in substrate specificity between VHR, the PTPs, and other DSPs.

About this Structure

1VHR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the dual specificity protein phosphatase VHR., Yuvaniyama J, Denu JM, Dixon JE, Saper MA, Science. 1996 May 31;272(5266):1328-31. PMID:8650541 Page seeded by OCA on Sat May 3 12:33:00 2008

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OCA

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