1vif

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[[Image:1vif.jpg|left|200px]]
[[Image:1vif.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1vif |SIZE=350|CAPTION= <scene name='initialview01'>1vif</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1vif", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= SYNTHETIC GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1vif| PDB=1vif | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vif OCA], [http://www.ebi.ac.uk/pdbsum/1vif PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vif RCSB]</span>
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}}
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'''STRUCTURE OF DIHYDROFOLATE REDUCTASE'''
'''STRUCTURE OF DIHYDROFOLATE REDUCTASE'''
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[[Category: Narayana, N.]]
[[Category: Narayana, N.]]
[[Category: Xuong, N H.]]
[[Category: Xuong, N H.]]
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[[Category: nadp]]
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[[Category: Nadp]]
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[[Category: one-carbon metabolism]]
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[[Category: One-carbon metabolism]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: plasmid]]
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[[Category: Plasmid]]
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[[Category: trimethoprim resistance methotrexate resistance]]
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[[Category: Trimethoprim resistance methotrexate resistance]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:34:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:24:56 2008''
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Revision as of 09:34, 3 May 2008

Image:1vif.jpg

Template:STRUCTURE 1vif

STRUCTURE OF DIHYDROFOLATE REDUCTASE


Overview

Bacteria expressing R67-plasmid encoded dihydrofolate reductase (R67 DHFR) exhibit high-level resistance to the antibiotic trimethoprim. Native R67 DHFR is a 34,000 M(r) homotetramer which exists in equilibrium with an inactive dimeric form. The structure of native R67 DHFR has now been solved at 1.7 A resolution and is unrelated to that of chromosomal DHFR. Homotetrameric R67 DHFR has an unusual pore, 25 A in length, passing through the middle of the molecule. Two folate molecules bind asymmetrically within the pore indicating that the enzyme's active site consists of symmetry related binding surfaces from all four identical units.

About this Structure

1VIF is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site., Narayana N, Matthews DA, Howell EE, Nguyen-huu X, Nat Struct Biol. 1995 Nov;2(11):1018-25. PMID:7583655 Page seeded by OCA on Sat May 3 12:34:02 2008

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