Spermidine Synthase

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Line 46: Line 46:
**[[2pt6]], [[3rie]], [[4bp3]], [[4bp1]] - PfSPS + inhibitor + methylthioadenosine<br />
**[[2pt6]], [[3rie]], [[4bp3]], [[4bp1]] - PfSPS + inhibitor + methylthioadenosine<br />
**[[2pt9]] - PfSPS + inhibitor + SAM derivative<br />
**[[2pt9]] - PfSPS + inhibitor + SAM derivative<br />
-
**[[4cwa]] - PfSPS + inhibitor + ethanol derivative<br />
+
**[[4cwa]], [[5b1s]] - PfSPS + inhibitor + ethanol derivative<br />
**[[4yv0]], [[4yv1]], [[4yv2]], [[4yuv]], [[4yuw]], [[4yux]], [[4yuy]], [[4yuz]] - TcSPS + inhibitor + SAM derivative<br />
**[[4yv0]], [[4yv1]], [[4yv2]], [[4yuv]], [[4yuw]], [[4yux]], [[4yuy]], [[4yuz]] - TcSPS + inhibitor + SAM derivative<br />

Revision as of 17:21, 5 October 2017

Structure of human spermidine synthase complex with spermidine and deoxymethyladenosine (PDB entry 3c6k)

Drag the structure with the mouse to rotate

3D structures of spermidine synthase

Updated on 05-October-2017

References

  1. Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, Pegg AE, Plotnikov AN. Structure and mechanism of spermidine synthases. Biochemistry. 2007 Jul 17;46(28):8331-9. Epub 2007 Jun 22. PMID:17585781 doi:http://dx.doi.org/10.1021/bi602498k
  2. Schwartz CE, Wang X, Stevenson RE, Pegg AE. Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome). Methods Mol Biol. 2011;720:437-45. doi: 10.1007/978-1-61779-034-8_28. PMID:21318891 doi:http://dx.doi.org/10.1007/978-1-61779-034-8_28
  3. Wu H, Min J, Zeng H, McCloskey DE, Ikeguchi Y, Loppnau P, Michael AJ, Pegg AE, Plotnikov AN. Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J Biol Chem. 2008 Jun 6;283(23):16135-46. Epub 2008 Mar 26. PMID:18367445 doi:http://dx.doi.org/10.1074/jbc.M710323200

Created with the participation of Lindsey Butler.

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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