Histone acetyltransferase
From Proteopedia
(Difference between revisions)
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *Histone acetyltransferase | + | *Histone acetyltransferase; Human domains – catalytic domain residues 497-662; bromodomain residues 729-837; |
**[[1qso]] - yHAT HPA2 – yeast<br /> | **[[1qso]] - yHAT HPA2 – yeast<br /> | ||
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**[[3gg3]] - hHAT PCAF bromodomain | **[[3gg3]] - hHAT PCAF bromodomain | ||
| - | **[[3i3j]] – hHAT P300 bromodomain | ||
| - | |||
| - | **[[3io2]] – hHAT P300 TAZ2 domain<br /> | ||
| - | **[[3biy]] – hHAT P300 AT domain<br /> | ||
| - | **[[4bhw]] - hHAT P300 core (mutant)<br /> | ||
**[[2ou2]] - hHAT HTATIP<br /> | **[[2ou2]] - hHAT HTATIP<br /> | ||
**[[2eko]] – hHAT HTATIP histone tail-binding domain - NMR | **[[2eko]] – hHAT HTATIP histone tail-binding domain - NMR | ||
| - | **[[1z4r]] – hHAT | + | **[[1z4r]] – hHAT catalytic domain<br /> |
**[[3toa]] - hHAT Myst1 residues 177-447<br /> | **[[3toa]] - hHAT Myst1 residues 177-447<br /> | ||
**[[3tob]] - hHAT Myst1 residues 177-447 (mutant)<br /> | **[[3tob]] - hHAT Myst1 residues 177-447 (mutant)<br /> | ||
| - | **[[2rc4]] – hHAT Myst3 | + | **[[2rc4]] – hHAT Myst3 acetyltransferase domain<br /> |
| + | **[[5trm]] - hHAT KAT2A catalytic domain <br /> | ||
**[[4nsq]] - hHAT KAT2B<br /> | **[[4nsq]] - hHAT KAT2B<br /> | ||
**[[4qqg]] - hHAT KAT5 N terminal<br /> | **[[4qqg]] - hHAT KAT5 N terminal<br /> | ||
**[[2ln0]] - hHAT KAT6A<br /> | **[[2ln0]] - hHAT KAT6A<br /> | ||
**[[4ljn]] - hHAT KAT6A double PHD finger<br /> | **[[4ljn]] - hHAT KAT6A double PHD finger<br /> | ||
| + | **[[5wci]] - hHAT KAT8 residues 174-449 <br /> | ||
**[[5j8c]], [[5j8f]] - hHAT KAT8 residues 177-447 (mutant)<br /> | **[[5j8c]], [[5j8f]] - hHAT KAT8 residues 177-447 (mutant)<br /> | ||
**[[2qec]] – HAT HPA2 (mutant) – ''Corynebacterium glutamicum'' | **[[2qec]] – HAT HPA2 (mutant) – ''Corynebacterium glutamicum'' | ||
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**[[5gcn]] – TtHAT Gcn5 + CoA – ''Tetrahymena thermophila'' - NMR<br /> | **[[5gcn]] – TtHAT Gcn5 + CoA – ''Tetrahymena thermophila'' - NMR<br /> | ||
| - | **[[2mh0]] - hHAT P300 zinc finger + transcription factor ITF-1<br /> | ||
| - | **[[2mh0]], [[2k8f]] - hHAT P300 zinc finger (mutant) + p53 peptide<br /> | ||
| - | **[[4pzr]], [[4pzs]] - hHAT P300 acetyltransferase domain (mutant) + acetyl CoA<br /> | ||
| - | **[[4pzt]] - hHAT P300 acetyltransferase domain (mutant) + acetonyl CoA<br /> | ||
| - | **[[5lkt]] - hHAT P300 residues 1581-1666 + butyryl CoA<br /> | ||
| - | **[[5lku]] - hHAT P300 catalytic core + CoA<br /> | ||
| - | **[[5lkx]] - hHAT P300 catalytic core (mutant) + propionyl CoA<br /> | ||
| - | **[[5lkz]] - hHAT P300 catalytic core (mutant) + crotonyl CoA<br /> | ||
| - | **[[5bt3]] - hHAT P300 bromodomain + inhibitor<br /> | ||
**[[1wug]], [[1wum]] – hHAT PCAF + small ligand | **[[1wug]], [[1wum]] – hHAT PCAF + small ligand | ||
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**[[2rnw]], [[2rnx]] - hHAT PCAF bromodomain + histone H3 peptide - NMR<br /> | **[[2rnw]], [[2rnx]] - hHAT PCAF bromodomain + histone H3 peptide - NMR<br /> | ||
| - | **[[5h84]] - hHAT KAT2A + propionyl CoA<br /> | + | **[[5h84]] - hHAT KAT2A catalytic domain + propionyl CoA<br /> |
| - | **[[5h86]] - hHAT KAT2A + butyryl CoA<br /> | + | **[[5h86]] - hHAT KAT2A catalytic domain + butyryl CoA<br /> |
| - | **[[5lvq]], [[5lvr]], [[5fdz]], [[5fe0]], [[5fe1]], [[5fe2]], [[5fe3]], [[5fe4]], [[5fe5]], [[5fe6]], [[5fe7]], [[5fe8]], [[5fe9]] - hHAT KAT2B bromodomain + inhibitor<br /> | + | **[[5trl]] - hHAT KAT2A catalytic domain + succinyl CoA<br /> |
| + | **[[5mlj]] - hHAT KAT2A bromodomain + inhibitor<br /> | ||
| + | **[[5lvq]], [[5lvr]], [[5fdz]], [[5fe0]], [[5fe1]], [[5fe2]], [[5fe3]], [[5fe4]], [[5fe5]], [[5fe6]], [[5fe7]], [[5fe8]], [[5fe9]], [[5mkx]] - hHAT KAT2B bromodomain + inhibitor<br /> | ||
**[[4dnc]] – hHAT KAT8 HAT domain + male-specific lethal 1 homolog<br /> | **[[4dnc]] – hHAT KAT8 HAT domain + male-specific lethal 1 homolog<br /> | ||
| - | **[[3v43]], [[4lk9]], [[4lka]] | + | **[[3v43]], [[4lk9]], [[4lka]], [[4llb]], [[5b75]], [[5b76]], [[5b77]], [[5b78]] - hHAT KAT6A + H3.1 peptide<br /> |
**[[5u2j]] - hHAT KAT6B + H3K14BU peptide<br /> | **[[5u2j]] - hHAT KAT6B + H3K14BU peptide<br /> | ||
**[[5gk9]] - hHAT KAT7 + BRD1<br /> | **[[5gk9]] - hHAT KAT7 + BRD1<br /> | ||
**[[5tpx]] - HAT GCN5 + probe – ''Plasmodium falciparum''<br /> | **[[5tpx]] - HAT GCN5 + probe – ''Plasmodium falciparum''<br /> | ||
| + | **[[5ml0]] - HAT KAT2B bromodomain + inhibitor - mouse<br /> | ||
*Histone acetyltransferase ternary complexes | *Histone acetyltransferase ternary complexes | ||
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**[[1q2d]] - TtHAT Gcn5 + CoA + p53 peptide | **[[1q2d]] - TtHAT Gcn5 + CoA + p53 peptide | ||
| + | |||
| + | * Histone acetyltransferase P300; domains – core domain residues 1043-1519; bromodomain residues 1040-1161; acetyltransferase domain residues 1287-1664; TAZ2 domain 1723-1836: | ||
| + | |||
| + | **[[3i3j]] – hHAT P300 bromodomain <br /> | ||
| + | **[[3io2]] – hHAT P300 TAZ2 domain <br /> | ||
| + | **[[4bhw]] - hHAT P300 core (mutant)<br /> | ||
| + | **[[2mh0]] - hHAT P300 TAZ2 + transcription factor ITF-1<br /> | ||
| + | **[[2mh0]], [[2k8f]] - hHAT P300 TAZ2 (mutant) + p53 peptide<br /> | ||
| + | **[[4pzr]], [[4pzs]] - hHAT P300 acetyltransferase domain residues 1287-1664 (mutant) + acetyl CoA<br /> | ||
| + | **[[4pzt]] - hHAT P300 acetyltransferase domain (mutant) + acetonyl CoA<br /> | ||
| + | **[[5lkt]] - hHAT P300 residues 1581-1666 + butyryl CoA<br /> | ||
| + | **[[5lku]] - hHAT P300 core + CoA<br /> | ||
| + | **[[5lkx]] - hHAT P300 core (mutant) + propionyl CoA<br /> | ||
| + | **[[5lkz]] - hHAT P300 core (mutant) + crotonyl CoA<br /> | ||
| + | **[[3biy]] – hHAT P300 acetyltransferase domain residues 1287-1666 + lysine CoA derivative<br /> | ||
| + | **[[5bt3]], [[5nu5]], [[5lpk]], [[5lpm]] - hHAT P300 bromodomain + inhibitor<br /> | ||
| + | |||
**[[3p57]] - hHAT P300 TAZ2 domain + myocyte-specific enhancer factor 2A + DNA | **[[3p57]] - hHAT P300 TAZ2 domain + myocyte-specific enhancer factor 2A + DNA | ||
Revision as of 08:53, 19 June 2018
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3D Structures of histone acetyltransferase
Updated on 19-June-2018
References
- ↑ Roth SY, Denu JM, Allis CD. Histone acetyltransferases. Annu Rev Biochem. 2001;70:81-120. PMID:11395403 doi:10.1146/annurev.biochem.70.1.81
- ↑ Dekker FJ, van den Bosch T, Martin NI. Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases. Drug Discov Today. 2014 May;19(5):654-60. doi: 10.1016/j.drudis.2013.11.012. Epub, 2013 Nov 21. PMID:24269836 doi:http://dx.doi.org/10.1016/j.drudis.2013.11.012
- ↑ Van Beekum O, Kalkhoven E. Aberrant forms of histone acetyltransferases in human disease. Subcell Biochem. 2007;41:233-62. PMID:17484131
- ↑ Dutnall RN, Tafrov ST, Sternglanz R, Ramakrishnan V. Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily. Cell. 1998 Aug 21;94(4):427-38. PMID:9727486
