Sandbox 12004

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Tacrine was the first cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
Tacrine was the first cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
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Tacrine’s ringed structure is stacked between the aromatic rings of Trp84 and Phe330.<ref>PMID: 8415649 </ref>
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Tacrine’s ringed structure is stacked between the aromatic rings of <scene name='76/761693/Tacrine/1'>Trp84 and Phe330</scene>.<ref>PMID: 8415649 </ref>

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PDB ID 1acj

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References

  1. ↑ Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
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